Evidence map›Paper›PMID 41019589›Full record

ArticleMolecular therapy. Oncology2025

Targeting glioblastoma using oncolytic viruses delivered by human pluripotent stem cell-derived neural progenitor cells.

Jianfei Chao, Qi Cui, Peng Ye, Shyambabu Chaurasiya, Jonas Cerneckis, Yuman Fong, Yanhong Shi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Advancements in Drug Delivery Systems in Glioblastoma Therapy.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jianfei ChaoDepartment of Neurodegenerative Diseases, Beckman Research Institute of City of Hope, 1500 E. Duarte Road, Duarte, CA 91010, USA.
Qi CuiDepartment of Neurodegenerative Diseases, Beckman Research Institute of City of Hope, 1500 E. Duarte Road, Duarte, CA 91010, USA.
Peng YeDepartment of Neurodegenerative Diseases, Beckman Research Institute of City of Hope, 1500 E. Duarte Road, Duarte, CA 91010, USA.
Shyambabu ChaurasiyaDepartment of Surgery, City of Hope, 1500 E. Duarte Road, Duarte, CA 91010, USA.
Jonas CerneckisDepartment of Neurodegenerative Diseases, Beckman Research Institute of City of Hope, 1500 E. Duarte Road, Duarte, CA 91010, USA.
Yuman FongDepartment of Surgery, City of Hope, 1500 E. Duarte Road, Duarte, CA 91010, USA.
Yanhong ShiDepartment of Neurodegenerative Diseases, Beckman Research Institute of City of Hope, 1500 E. Duarte Road, Duarte, CA 91010, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor that has no cure. Oncolytic virotherapy is emerging as an effective approach to target cancer cells. Here, we show that the CF17 oncolytic virus, either delivered directly or by human pluripotent stem cell (hPSC)-derived neural progenitor cell (NPC) carrier, exerts strong growth inhibitory effect on GBM stem cells (GSCs)

Indexed as

glioblastomahuman induced pluripotent stem cellshuman pluripotent stem cellsiPSCsneural progenitor cellsoncolytic virotherapystem cell therapy

Identifiers

PMID41019589
PMCPMC12466230

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.