ArticleNIHR open research2025
Study Protocol: A retrospective observational analysis of patients treated for hospital-acquired pneumonia.
Article in NIHR open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
Background: Hospital-acquired pneumonia (HAP) is an important complication of hospital admission, with both high incidence and consequences for patients. However, our understanding of causative organisms and prognostic factors is limited. Although ventilator-associated pneumonia (VAP,) an important subset of HAP,has been extensively investigated, less is known about non-ventilated cases, leading to calls for focused research in this group. This retrospective observational cohort study aims to define a population of patients treated as HAP by comparing ventilated and non-ventilated cases. It aims to clarify how often a microbiological diagnosis is reached, what organisms are frequently identified, and whether this has a relevant impact on the outcomes. The relative impact of positive radiographic changes among patients treated for HAP will also be assessed. Methods: Data will be obtained from the Health Data Research UK acute care hub, 'PIONEER' Cases meeting coding criteria or a clinical surveillance definition of HAP over a 5-year period will be extracted. Demographic, clinical, and microbiological variables will be analysed initially descriptively, and subsequently, with multiple logistic regression analysis to investigate factors affecting microbiological diagnosis. Key outcome variables are in-hospital, 30-day and 1 year mortality, as well as all-cause readmissions within 1 year. Secondary outcomes include nosocomial infections, such as
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