Low-Dose Paracetamol Treatment Protects Neuronal Oxidative Stress and Neuroinflammation in D-Galactose-Induced Accelerated Aging Model.

Chuchard Punsawad, Paweena Kaewman, Tachpon Techarang, Diana Sketriene, Laddawan Lalert

Abstract read

In one paragraph

Article in Scientifica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

RhFGF21 Mitigated D-gal-triggered Learning and Memory Dysfunction in Mice by Inhibiting Oxidative Stress, Inflammation and Senescence in Cortex and Hippocampus via Modulating FGFR1 and SIRT1.Molecular neurobiology · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chuchard PunsawadDepartment of Medical Science, School of Medicine, Walailak University, Nakhon Si Thammarat 80160, Thailand.ORCID https://orcid.org/0000-0003-4826-9474

Paweena KaewmanDepartment of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.ORCID https://orcid.org/0000-0001-7431-4422

Tachpon TecharangDepartment of Tropical Pathology, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.ORCID https://orcid.org/0000-0002-9223-8926

Diana SketrieneDepartment of Biochemistry and Pharmacology, Medicine, Dentistry and Health Sciences, The University of Melbourne, Victoria 3010, Australia.ORCID https://orcid.org/0000-0002-6510-042X

Laddawan LalertCenter of Excellence in Medical Biotechnology, Naresuan University, Phitsanulok 65000, Thailand.ORCID https://orcid.org/0000-0003-4178-9282

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging increases the risk of neurodegenerative diseases such as Parkinson's and Alzheimer's (PD and AD) which are potentially linked to increased oxidative stress and inflammation. Paracetamol (APAP) is known for its antioxidant and anti-inflammatory properties; however, its potential neuroprotective effects against age-related oxidative stress and neuroinflammation remain inadequately investigated. Therefore, we aimed to examine whether low-dose APAP could mitigate oxidative stress and neuroinflammation in a D-galactose (D-gal)-induced aging model. In our study, fifty adult male ICR mice were divided into five groups (

Identifiers

PMID41019419

DOI10.1155/sci5/5559483

PMCPMC12463536

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.