ArticleMechanobiology in medicine2025
Mechanotransduction in neutrophil: Mechanosensing and immune function regulation.
Article in Mechanobiology in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Mechanical stress promotes excessive NETs and exacerbates acute lung injury via Piezo1-mediated mitochondrial dysfunction.Redox biology · 2026Article
- Piezo1 in respiratory diseases: mechanotransduction, cell-specific functions, and translational implications.Frontiers in physiology · 2026Review
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Authors and funding
3 authors.
Funding
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Abstract
Immune cells sense and transduce mechanical signals such as stiffness, stretch, compression, and shear stress. In the past few years, our understanding of the mechanosensitive signaling pathways in myeloid cells has significantly expanded, especially in monocytes, macrophages, and dendritic cells. Recently, the mechanobiological regulation of neutrophil function has been deciphered. Mechanical signals from tissue-derived shear stress and cellular deformation tension reprogram neutrophil transcription via GEF-H1, PIEZO1, and TRPV4 pathways, modulating neutrophil functions in homeostasis and trans-endothelial migration. Understanding these force-dependent processes provides novel insights into neutrophil plasticity and highlights potential therapeutic strategies and approaches for inflammatory and infectious diseases.
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Registered trials
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