ArticleNanotechnology, science and applications2025
Harnessing Cationic Bilosomes to Create a Green Light-Triggered Nanoplatform for Skin Melanoma Treatment.
Article in Nanotechnology, science and applications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Nanotechnology in Cutaneous Oncology: The Role of Liposomes in Targeted Melanoma Therapy.Molecules (Basel, Switzerland) · 2026Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Vesicular drug delivery systems, including bilosome-based nanoparticles containing bile salts, have revolutionized the field of colloid chemistry, nanomedicine, and nanobiotechnology. Due to their versatility and adaptability to various applications, they have gained considerable attention among researchers, thus offering a promising pathway to achieve effective and targeted delivery of miscellaneous drugs. Purpose: This study presents a novel class of positively charged bilosomes with surface-associated poly(ethylene glycol) (PEG)-lipid, co-entrapped the anionic xanthene dye (Rose Bengal), and natural carotenoid pigment derived from the mold Methods: Bilosomal nanosystems were prepared using thin film hydration combined with sonication. The physicochemical properties of the vesicles were characterized, including particle size, zeta potential, entrapment efficiency, and morphology. Cellular uptake, cyto- and phototoxicity experiments were investigated in vitro against human melanoma cancer cells. Results: The multidrug bilosome formulation exhibited a particle size of less than 100 nm and a zeta potential of more than +40 mV, indicating beneficial properties for potential transdermal administration. In vitro biological experiments have shown remarkable antitumor efficacy against human skin epithelial (A375) and malignant (Me45) melanoma cell lines. After irradiating the samples with green light at a wavelength of 520-560 nm (10 J/cm Conclusion: Our encouraging results provide new potential candidates for preclinical development in innovative photodynamic therapy targeting melanoma and also pave the way for future therapeutic strategies with broad applications in many biological fields.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.