ArticleFrontiers in endocrinology2025
Multimodal ultrasonography in the diagnosis and treatment of chronic thyrotoxic myopathy: a prospective study.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study integrates high-frequency ultrasonography with shear wave elastography (SWE) to perform a multimodal quantitative assessment of the rectus femoris and thyroid tissue architecture in patients with chronic thyrotoxic myopathy (CTM). A novel predictive model for CTM progression was developed by quantitatively assessing biomechanical parameters, including muscle and thyroid parenchymal stiffness, providing an objective imaging-based foundation for early disease intervention. Methods: This prospective study enrolled 75 patients with hyperthyroidism and 53 healthy controls. The biomechanical parameters of the rectus femoris and thyroid tissue were quantitatively assessed using SWE. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive efficacy of rectus femoris and thyroid tissue elasticity parameters for CTM diagnosis. A multivariate logistic regression model was developed to investigate the association between muscle stiffness, thyroid stiffness, and CTM risk. Additionally, patients with CTM received pharmacotherapeutic interventions, and clinical indexes were systematically monitored along with dynamic changes in thyroid and rectus femoris correlation parameters before and after treatment to evaluate therapeutic efficacy. Results: The CTM group exhibited a significantly lower mean Young's modulus (E-mean) of the rectus femoris than the non-CTM and healthy groups ( Conclusion: By quantitatively assessing the morphological and biomechanical characteristics of the rectus femoris and thyroid gland, multimodal ultrasonography can provide a reliable imaging basis for the early prediction and therapeutic monitoring of CTM.
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