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ArticleEuropean heart journal. Case reports2025

A multifaceted clinical portrait of Ebstein's anomaly: a case series.

Panayotis K Vlachakis, Eva Nyktari, George Oikonomou, Anastasios Apostolos, Skevos Sideris, Konstantinos Toutouzas, Costas Tsioufis, Maria Drakopoulou

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Panayotis K VlachakisAdult Congenital Heart Centre and Centre for Pulmonary Hypertension, First Cardiology Department, Hippokration General Hospital, Athens Medical School, National and Kapodistrian University of Athens, 114 Vasilissis Sophias, Athens 11527, Greece.
Eva NyktariCMR Unit, Onassis Cardiac Surgery Center, 356 Andrea Syggrou Avenue, Kallithea 17674, Greece.
George OikonomouAdult Congenital Heart Centre and Centre for Pulmonary Hypertension, First Cardiology Department, Hippokration General Hospital, Athens Medical School, National and Kapodistrian University of Athens, 114 Vasilissis Sophias, Athens 11527, Greece.
Anastasios ApostolosAdult Congenital Heart Centre and Centre for Pulmonary Hypertension, First Cardiology Department, Hippokration General Hospital, Athens Medical School, National and Kapodistrian University of Athens, 114 Vasilissis Sophias, Athens 11527, Greece.ORCID https://orcid.org/0000-0003-2616-7952
Skevos SiderisDepartment of Cardiology, Hippokration General Hospital, 114 Vasilissis Sophias, Athens 11527, Greece.ORCID https://orcid.org/0000-0003-3165-224X
Konstantinos ToutouzasAdult Congenital Heart Centre and Centre for Pulmonary Hypertension, First Cardiology Department, Hippokration General Hospital, Athens Medical School, National and Kapodistrian University of Athens, 114 Vasilissis Sophias, Athens 11527, Greece.ORCID https://orcid.org/0000-0003-2946-344X
Costas TsioufisAdult Congenital Heart Centre and Centre for Pulmonary Hypertension, First Cardiology Department, Hippokration General Hospital, Athens Medical School, National and Kapodistrian University of Athens, 114 Vasilissis Sophias, Athens 11527, Greece.
Maria DrakopoulouAdult Congenital Heart Centre and Centre for Pulmonary Hypertension, First Cardiology Department, Hippokration General Hospital, Athens Medical School, National and Kapodistrian University of Athens, 114 Vasilissis Sophias, Athens 11527, Greece.ORCID https://orcid.org/0000-0002-0022-0332

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: It was in 1866 when Wilhelm Ebstein first described a rare case of a 19-year-old cyanotic patient with tricuspid valve regurgitation caused by a congenital malformation. Since then, Ebstein's anomaly (EA) has been recognized as a condition that exhibits a diverse clinical course with a formidable challenge for clinicians in terms of diagnosis, management, and prognosis. Case summary: We present a case series of four patients with EA, shedding light on the varied clinical manifestations, treatment approaches, and outcomes that underscore the multifaceted nature of this condition. Discussion: The management of EA requires a comprehensive and individualized approach in specialized centres. The cardiologists responsible for the long-term care of these patients are faced with various challenging 'dilemmas' in the clinical course of the disease at different stages. The evolving landscape of cardiology offers a promising avenue for improving the outcomes and quality of life of patients with EA.

Indexed as

Accessory pathwayCase reportEbstein’s anomalyRight ventricleTricuspid regurgitationValve-in-valve

Identifiers

PMID41019305
PMCPMC12461249

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.