Evidence map›Paper›PMID 41019234›Full record

ReviewInternational journal of nanomedicine2025

The Role of Piezoelectric Materials in Bone Remodeling and Repair: Mechanisms and Applications.

Wenjie Yue, Wanhao Zhang, Jing Zhang, Wenhe Qin, Xiaomei Bie, Yantao Zhao, Gang Xu

Abstract readReview
In one paragraph

Review in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wenjie YueDepartment of Orthopaedics, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People's Republic of China.
Wanhao ZhangDepartment of Orthopaedics, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People's Republic of China.
Jing ZhangDepartment of Orthopaedics, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People's Republic of China.
Wenhe QinDepartment of Orthopaedics, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People's Republic of China.
Xiaomei BieOutpatient Department, Fourth Medical Center of the General Hospital of CPLA, Beijing, 100048, People's Republic of China.
Yantao ZhaoSenior Department of Orthopedics, Fourth Medical Center of the General Hospital of CPLA, Beijing, 100048, People's Republic of China.
Gang XuDepartment of Orthopaedics, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People's Republic of China.ORCID 0000-0002-3550-2882

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bones can sense bioelectricity. The process of bone remodeling and repair needs complex physiological signals like bioelectric, biochemical, and biomechanical factors, which work together to promote bone recovery. The formation, healing, and regeneration of natural bones are intricately linked to the influence of electrical signals. Piezoelectric materials have piezoelectric properties similar to bones, making them suitable for bone like repair. This study systematically summarizes the role of piezoelectric materials in bone remodeling and repair, as well as their related preparation techniques. Subsequently, the piezoelectric mechanism of bones is explored in depth, including the study of bone composition, analysis of piezoelectric and osteogenic mechanisms, and research progress on piezoelectric stimulation guided bone regeneration and repair. Through these analyses, the principle of how piezoelectric materials interact with bones to promote bone repair and remodeling has been further understood. Finally, the article analyzes the mechanism of piezoelectric materials on bone remodeling and repair, revealing how piezoelectric stimulation promotes bone regeneration and repair. These findings offer theoretical foundation and practical guidance for the further application of piezoelectric materials in orthopedics.

Indexed as

Bone RegenerationBone RemodelingAnimalsBone and BonesHumansOsteogenesisBioelectricityBone remodeling and repairOsteogenic mechanismPhysiological signalsPiezoelectric materialPiezoelectric stimulation

Identifiers

PMID41019234
PMCPMC12474723

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.