Evidence map›Paper›PMID 41019116›Full record

ArticleACS central science2025

Astragaloside IV Alleviates Fructose-Induced Intestinal Metabolic Senescence by Targeting Ketohexokinase Asn261/Ala226 to Preserve Intestinal Stem Cell Homeostasis.

Qifang Wu, Yingna Li, Yunyun Zhao, Ruifen Zhang, Jingyang Tong, Chunlei Ji, Yiming Zhao, Mingjiang Wu, Xiaosheng Jin, Dandan Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS central science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Qifang WuResearch Center of Traditional Chinese Medicine, College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130021, China.
Yingna LiResearch Center of Traditional Chinese Medicine, College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130021, China.
Yunyun ZhaoDepartment of Endocrinology and Metabolism, Affiliated Hospital to Changchun University of Chinese Medicine, Changchun 130021, China.
Ruifen ZhangCollege of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China.
Jingyang TongCollege of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China.
Chunlei JiResearch Center of Traditional Chinese Medicine, College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130021, China.
Yiming ZhaoResearch Center of Traditional Chinese Medicine, College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130021, China.
Mingjiang WuCollege of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China.
Xiaosheng JinDepartment of Gastroenterology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, China.
Dandan WangResearch Center of Traditional Chinese Medicine, College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130021, China.
Haibin TongCollege of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China.ORCID https://orcid.org/0000-0002-7645-3458
Liwei SunResearch Center of Traditional Chinese Medicine, College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130021, China.
Fangbing LiuNortheast Asian Institute of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130021, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excessive fructose intake drives intestinal aging and impairs intestinal stem cell (ISC) function, yet effective therapeutic interventions remain elusive. Astragaloside IV (AS-IV), a natural saponin from

Identifiers

PMID41019116
PMCPMC12464770

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.