Evidence map›Paper›PMID 41019108›Full record

ArticleACS central science2025

A Synthetic Phage-Peptide Conjugate as a Potent Antibacterial Agent for

Yanxi Yang, Shelby Vexler, Maria C Jordan, Serena Abbondante, Dayeon Kang, Huan Peng, Michaela Marshall, Bita V Naini, Saumya Jain, Yei-Chen Lai and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS central science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yanxi YangDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095, United States.
Shelby VexlerDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095, United States.ORCID https://orcid.org/0000-0001-7844-5390
Maria C JordanDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, United States.
Serena AbbondanteDepartment of Ophthalmology, School of Medicine, University of California, Irvine, California 92697, United States.
Dayeon KangDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095, United States.
Huan PengCellular Signaling Laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, College of Life Science and Technology, Huazhong University of Science and Technology, 430074 Wuhan, Hubei, China.ORCID https://orcid.org/0000-0001-6799-946X
Michaela MarshallDepartment of Ophthalmology, School of Medicine, University of California, Irvine, California 92697, United States.ORCID https://orcid.org/0000-0001-9381-780X
Bita V NainiDepartment of Pathology & Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, United States.
Saumya JainDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095, United States.
Yei-Chen LaiDepartment of Chemistry, National Chung Hsing University, Taichung City 402, Taiwan.ORCID https://orcid.org/0000-0002-5723-5412
Nasim AnnabiDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095, United States.ORCID https://orcid.org/0000-0003-1879-1202
Kenneth P RoosDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, United States.
Eric PearlmanDepartment of Ophthalmology, School of Medicine, University of California, Irvine, California 92697, United States.
Irene A ChenDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095, United States.ORCID https://orcid.org/0000-0001-6040-7927

Funding

Phage-inspired engineering and evolutionR35GM148249 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Irene Ann Chen · 2023 to 2026
$1.5M
NIGMS NIH HHS R35 GM148249
6 · The paper itself

Abstract

Antibiotic resistance among Gram-negative organisms is a major challenge. Some molecules, including antimicrobial peptides such as polymyxin B (PMB), are antibacterial but toxic due to low specificity, causing poor clinical utility. Drug delivery to bacterial cells using a biocompatible nanomaterial is a possible approach to securing such drugs. We engineered a nonlytic phage to recognize the lipopolysaccharide of Gram-negative bacteria and cross-linked thousands of peptides per virion, making "PMB-M13

Identifiers

PMID41019108
PMCPMC12464783

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.