Evidence map›Paper›PMID 41019102›Full record

ArticleACS central science2025

Immunomodulatory Nanoparticles Enable Combination Therapies To Enhance Disease Prevention and Flare Control in Rheumatoid Arthritis.

Wade T Johnson, Elizabeth L Wilkinson, Neha Iyer, Maksim Dolmat, Miriam Bollmann, Nour Dada, Xiaofu Wei, Shen Yang, Tiffany Zhang, Grace Yoo and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS central science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Wade T JohnsonDepartment of Chemical and Nano Engineering, University of California San Diego, La Jolla, California 92093, United States.ORCID https://orcid.org/0000-0002-0810-6454
Elizabeth L WilkinsonDepartment of Chemical and Nano Engineering, University of California San Diego, La Jolla, California 92093, United States.
Neha IyerDepartment of Chemical and Nano Engineering, University of California San Diego, La Jolla, California 92093, United States.
Maksim DolmatDepartment of Chemical and Nano Engineering, University of California San Diego, La Jolla, California 92093, United States.ORCID https://orcid.org/0000-0002-4918-7342
Miriam BollmannDepartment of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg 41346, Sweden.
Nour DadaDepartment of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg 41346, Sweden.
Xiaofu WeiDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, California 92093, United States.
Shen YangKao Autoimmunity Institute and Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California 90048, United States.
Tiffany ZhangKao Autoimmunity Institute and Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California 90048, United States.ORCID https://orcid.org/0000-0002-2832-7895
Grace YooKao Autoimmunity Institute and Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California 90048, United States.
Marianne BernardoKao Autoimmunity Institute and Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California 90048, United States.
Madison PriceKao Autoimmunity Institute and Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California 90048, United States.
Elizabeth FrameKao Autoimmunity Institute and Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California 90048, United States.
Mariko IshimoriKao Autoimmunity Institute and Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California 90048, United States.
Jon T GilesKao Autoimmunity Institute and Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California 90048, United States.
Wei WangDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, California 92093, United States.
Mattias N D SvenssonDepartment of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg 41346, Sweden.ORCID https://orcid.org/0000-0001-8077-9824
Nunzio BottiniKao Autoimmunity Institute and Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, California 90048, United States.
Nisarg J ShahDepartment of Chemical and Nano Engineering, University of California San Diego, La Jolla, California 92093, United States.ORCID https://orcid.org/0000-0003-1727-5732

Funding

Rheumatic Diseases Research Training GrantT32AR064194 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GARY S FIRESTEIN, Monica Guma · 2013 to 2026
$3.8M
Intra-Articular Drug Delivery Modulating Immune Cells in Inflammatory Joint DiseaseR01AR081887 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZHANG, LIANGFANG · 2023 to 2025
$1.8M
Immunoregulatory biomaterials for modulating arthritis flaresF31AR083236 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOHNSON, WADE TRUMAN · 2024 to 2024
$42k
NIAMS NIH HHS F31 AR083236NIAMS NIH HHS R01 AR081887NIAMS NIH HHS T32 AR064194
6 · The paper itself

Abstract

Disease-modifying antirheumatic drugs (DMARDs) have greatly improved the treatment of rheumatoid arthritis (RA), but strategies to prevent disease onset and recurring flares remain limited. While abatacept (CTLA-4 IgG) can delay RA onset and corticosteroids are used for flare control, the benefit is temporary. We report that combining standard-of-care treatments with a locally administered immunomodulatory agent, termed Agg-CLNP, enhances both disease prevention and flare mitigation. Agg-CLNP consists of polymer nanoparticles conjugated with an immunodominant aggrecan peptide and encapsulate calcitriol. These nanoparticles are optimized for uptake by dendritic cells (DC) in lymph nodes proximal to arthritic joints.

Identifiers

PMID41019102
PMCPMC12464772

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.