ArticleJournal of clinical tuberculosis and other mycobacterial diseases2025
Article in Journal of clinical tuberculosis and other mycobacterial diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Screening and tuberculosis preventive treatment among household contacts of drug-resistant tuberculosis patients: a scoping review.BMC infectious diseases · 2026Article
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12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Rifampicin-resistant tuberculosis (RR-TB) is a major global public health challenge. Household close contacts (HHCs) of RR-TB patients face a high risk of Methods: Using a cross-sectional design, HHCs of RR-TB patients diagnosed at Chengdu Public Health Clinical Medical Center from October 1, 2023, to March 30, 2025, were enrolled. Clinical data were collected via a self-designed questionnaire including gender, age, body mass index (BMI), relationship to index case, living environment, chronic comorbidities, medication history, and TBD-suspicious symptom screening. TBD screening used chest digital radiography (DR) or computed tomography (CT). Clinical data of index cases were extracted from the hospital information system (HIS), covering sputum acid-fast bacillus smear, sputum mycobacterial culture, sputum molecular testing for M. tuberculosis, fluoroquinolone resistance, extent of pulmonary lesions, and cavitation status. TB infection screening employed tuberculin skin test (TST), ESAT6-CFP10 fusion protein skin test (EC), or interferon-γ release assays (IGRA). Infection status was categorized as uninfected, LTBI, or TBD based on screening results, clinical symptoms, and imaging findings. Incidence rates of LTBI and TBD were calculated. Chi-square tests compared clinical characteristics across infection states. Multivariable logistic regression analyzed factors associated with LTBI and TBD (versus uninfected). Results: 264 HHCs from 197 RR-TB index cases were included: 113 males (42.8 %), 151 females (57.2 %), aged 3-78 years (mean 42.4 ± 15.1). Among 209 participants tested with TST: 117 (44.3 %) had induration diameter [0, 5) mm, 17 (6.4 %) [5, 10) mm, 30 (11.4 %) [10, 15) mm, 45 (17.1 %) ≥ 15 mm. Among 46 EC-tested: 29 (11.0 %) had [0, 5) mm, 17 (6.4 %) ≥ 5 mm. Among 9 IGRA-tested: 1 (0.4 %) negative, 8 (3.0 %) positive. After cluster-effect adjustment, LTBI incidence was 31.2 % (95 % confidence interval [CI]: 25.8-38.3), TBD incidence 9.9 % (95 % CI: 6.4-13.6). The proportion of spousal relationships to index cases was higher in LTBI/TBD groups than uninfected (P < 0.05). BMI < 18.5 kg/m Conclusion: High LTBI and TBD rates exist among RR-TB HHCs in this region. Spousal relationship is a risk factor for both LTBI and TBD; positive TBD symptoms and pulmonary cavitation in index cases correlate with TBD. Active screening for RR-TB HHCs and risk-stratified control strategies are recommended to block transmission chains.
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