Evidence map›Paper›PMID 41018924›Full record

ArticleRegenerative biomaterials2025

The use of concentrated growth factors in guiding bone regeneration after microsurgical endodontic surgery for periapical lesions.

Qi Lin, Shaofeng Liu, Minmin Wang, Zhongxiong Ma, Bin Shi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qi LinDepartment of Endodontics, Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Laboratory of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, 246 Yangqiao Zhong Road, Fuzhou, Fujian, 350001, People's Republic of China.
Shaofeng LiuDepartment of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Fujian Medical University, 20 Cha Zhong Road, Fuzhou, Fujian, 350002, People's Republic of China.
Minmin WangDepartment of Endodontics, Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Laboratory of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, 246 Yangqiao Zhong Road, Fuzhou, Fujian, 350001, People's Republic of China.
Zhongxiong MaDepartment of Endodontics, Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Laboratory of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, 246 Yangqiao Zhong Road, Fuzhou, Fujian, 350001, People's Republic of China.
Bin ShiDepartment of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Fujian Medical University, 20 Cha Zhong Road, Fuzhou, Fujian, 350002, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Concentrated growth factors (CGFs) hold great potentials for postoperative bone regeneration. This study attempted to investigate the effect of CGF scaffolds on guided bone regeneration after microsurgical endodontic surgery on teeth with periapical lesions. Microsurgical endodontic surgery was performed on 68 teeth with periapical lesions after complete root canal therapy. Autologous CGFs were administered to 38 teeth (the experimental group) while the remaining teeth received no CGF (the control group). The patients were followed for an average of 18 months. Postoperative pain, swelling and the duration were compared between the two groups. The bone volume ratios were quantitatively measured and statistically analyzed with Mimics software. Compared with the control group, the experimental group reported a lower incidence and shorter duration of postoperative pain and swelling, with mild to moderate swelling in the former and mild swelling in the latter. Both groups demonstrated good postoperative wound healing. The experimental group reported a significant reduction in bone volume ratio at postoperative month 3 (

Indexed as

biomaterialconcentrated growth factorsguided bone regenerationscaffold

Identifiers

PMID41018924
PMCPMC12461709

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.