Evidence map›Paper›PMID 41018888›Full record

ArticlePsoriasis (Auckland, N.Z.)2025

Vunakizumab for Treatment of Acrodermatitis Continua of Hallopeau: A Case Report and Literature Review.

Yi Yao, Yingming Ma, Huajie Zhong, Feiying Guo, Jiling Zhu, Yuan Wu, Shunli Tang

Abstract readCase Reports
In one paragraph

Article in Psoriasis (Auckland, N.Z.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yi Yao *Department of Dermatology, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou, People's Republic of China.
Yingming Ma *Department of Dermatology, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou, People's Republic of China.
Huajie Zhong *Department of Dermatology, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou, People's Republic of China.
Feiying GuoDepartment of Dermatology, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou, People's Republic of China.
Jiling ZhuDepartment of Dermatology, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou, People's Republic of China.
Yuan WuDepartment of Dermatology, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou, People's Republic of China.
Shunli TangDepartment of Dermatology, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acrodermatitis continua of Hallopeau (ACH) is a rare pustular psoriasis subtype, characterized by recurrent sterile pustules on digits, progressive nail deformation and atrophy. ACH is often refractory to different therapeutic modalities, presenting challenges in clinical practice. Emerging evidence indicates that elevated IL-17 levels modulate keratinocyte proliferation and immune cell infiltration, contributing to ACH pathogenesis and representing a promising therapeutic target. Herein, we presented a case of ACH successfully treated with vunakizumab, China's first self-developed anti-IL-17A monoclonal antibody, and reviewed publications reporting IL-17 targeted therapies for ACH, highlighting the potential benefit of IL-17 targeted therapy in ACH management.

Indexed as

acrodermatitis continua of hallopeauinterleukin-17pustular psoriasisvunakizumab

Identifiers

PMID41018888
PMCPMC12476186

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.