ReviewNature and science of sleep2025
Pathophysiological Insights and Multimodal Interventions in Chronic Tinnitus, Anxiety, and Sleep Disorders.
Review in Nature and science of sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Auditory Biofeedback through Wind Instrument Training: A Breath-Controlled Acoustic Strategy for Modulating Anxiety and Sleep.Noise & healthPooled it
- Dyadic Associations Between Stress and Sleep Quality and Moderating Effects of Emotional Intimacy and in Survivors of Young Adult Cancer and Their Spouses: An Observational Study.Psycho-oncology · 2026Observational
- Application of neurodegenerative disease treatment strategies in tinnitus: mechanisms, translation, and prospects.Frontiers in aging neuroscience · 2026Review
- Vicious cycle: the bidirectional relationship and pathophysiological mechanisms of tinnitus and sleep disturbance.Frontiers in neurology · 2026Review
- Development and comparison of machine learning models for predicting moderate-to-severe tinnitus in patients with hearing loss.Frontiers in neurology · 2025Article
- Associations between cochlear electrophysiology, emotional health, and sleep quality in adults with tinnitus: a comprehensive analysis.Frontiers in psychiatry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic subjective tinnitus (CST) is frequently accompanied by anxiety and sleep disturbances, together forming a self-reinforcing cycle that significantly impairs patients' quality of life and complicates clinical management. This narrative review aims to elucidate the shared pathophysiological mechanisms underlying these interrelated conditions and to evaluate current multidisciplinary therapeutic strategies. Relevant literature was identified through a targeted search of PubMed, Scopus, and Web of Science databases, focusing on recent clinical and translational studies addressing the neurobiology and treatment of CST, anxiety, and sleep disorders. Emerging evidence highlights the involvement of maladaptive auditory-limbic network connectivity, neurotransmitter imbalances (eg, GABA, glutamate, serotonin), dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, autonomic dysfunction, and disruption of circadian and sleep-wake regulatory pathways in the persistence and mutual reinforcement of these symptoms. Multimodal interventions-including cognitive behavioral therapy, sound therapy, pharmacotherapy, neuromodulation techniques, and targeted sleep interventions-have demonstrated synergistic benefits, particularly when tailored to individual neurobiological profiles. From a clinical perspective, recognizing the bidirectional interactions among tinnitus, affective dysregulation, and sleep impairment is essential for developing effective, integrative treatment frameworks. This review underscores the necessity of personalized, mechanism-informed therapeutic approaches and outlines key directions for future research.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.