Evidence map›Paper›PMID 41018806›Full record

ArticleJournal of the American Statistical Association2025

Data fusion using weakly aligned sources.

Sijia Li, Peter B Gilbert, Rui Duan, Alex Luedtke

Abstract read
In one paragraph

Article in Journal of the American Statistical Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Combining Observational Studies to Reduce Multiple Biases.Epidemiology (Cambridge, Mass.) · 2026
    Article
  2. Article
  3. A Review of Methods for Research Synthesis.Statistics in medicine · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sijia LiDepartment of Biostatistics, University of Washington.
Peter B GilbertDepartment of Biostatistics, University of Washington; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center.
Rui DuanDepartment of Biostatistics, Harvard T.H. Chan School of Public Health.
Alex LuedtkeDepartment of Statistics, University of Washington.

Funding

SDMC: HIV Vaccine Trials NetworkUM1AI068635 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Peter B. Gilbert, Yunda Huang · 2011 to 2026
$385.9M
Leadership for HIV/AIDS Clinical Trials Networks; HIV Vaccine Trials NetworkU01AI068635 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI SELF, STEVEN G. · 2006 to 2010
$53.8M
Statistical Methods in HIV Vaccine Efficacy TrialsR37AI054165 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Peter B. Gilbert · 2010 to 2026
$6.7M
High-Resolution Inference for Correlates of Vaccine ProtectionDP2LM013340 · NLM · UNIVERSITY OF WASHINGTON · PI LUEDTKE, ALEX · 2019 to 2019
$2.3M
Federated and transfer learning methods for cross-ancestry and cross-phenotype integration of genomic datasetsR01GM148494 · NIGMS · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Rui Duan · 2023 to 2026
$1.7M
NIAID NIH HHS R37 AI054165NIAID NIH HHS U01 AI068635NIAID NIH HHS UM1 AI068635NIGMS NIH HHS R01 GM148494NLM NIH HHS DP2 LM013340
6 · The paper itself

Abstract

We introduce a new data fusion method that utilizes multiple data sources to estimate a smooth, finite-dimensional parameter. Most existing methods only make use of fully aligned data sources that share common conditional distributions of one or more variables of interest. However, in many settings, the scarcity of fully aligned sources can make existing methods require unduly large sample sizes to be useful. Our approach enables the incorporation of weakly aligned data sources that are not perfectly aligned, provided their degree of misalignment is known up to finite-dimensional parameters. We quantify the additional efficiency gains achieved through the integration of these weakly aligned sources. We characterize the semiparametric efficiency bound and provide a general means to construct estimators achieving these efficiency gains. We illustrate our results by fusing data from two harmonized HIV monoclonal antibody prevention efficacy trials to study how a neutralizing antibody biomarker associates with HIV genotype.

Indexed as

data integrationHIVsemiparametric efficiency

Identifiers

PMID41018806
PMCPMC12467793

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.