Evidence map›Paper›PMID 41018707›Full record

ArticleOpen forum infectious diseases2025

Effectiveness and Safety of Antibiotics in Kidney Transplant Recipients With Asymptomatic Bacteriuria: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Abdullah Tarik Aslan, Lokman Hekim Tanriverdi, Adrian V Hernandez, Umut Akova, Kursat Kutluca, Samuel Chan, Julien Coussement, Arreola Guerra Jose Manuel, Julia Origüen, Núria Sabé and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Abdullah Tarik AslanFaculty of Medicine, UQ Centre for Clinical Research, University of Queensland, Brisbane, Queensland, Australia.
Lokman Hekim TanriverdiFaculty of Medicine, Department of Medical Pharmacology, Inönü University, Malatya, Turkiye.ORCID https://orcid.org/0000-0003-4263-5234
Adrian V HernandezHealth Outcomes, Policy, and Evidence Synthesis (HOPES) Group, University of Connecticut School of Pharmacy, Storrs, Connecticut, USA.ORCID https://orcid.org/0000-0002-9999-4003
Umut AkovaEmory University School of Medicine, Faculty of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-1768-0503
Kursat KutlucaSchool of Medicine, Hacettepe University, Ankara, Turkiye.ORCID https://orcid.org/0009-0000-9285-5863
Samuel ChanDepartment of Nephrology, Princess Alexandra Hospital, Brisbane, Australia.
Julien CoussementSir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0002-4302-6599
Arreola Guerra Jose ManuelDepartment of Nephrology, Hospital Centenario Miguel Hidalgo, Aguascalientes, Mexico.
Julia OrigüenDepartment of Infectious Diseases, Hospital Universitario "12 de Octubre,"  Madrid, Spain.ORCID https://orcid.org/0000-0002-6507-0363
Núria SabéDepartment of Infectious Diseases, Hospital Universitario de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
Patrick N A HarrisFaculty of Medicine, UQ Centre for Clinical Research, University of Queensland, Brisbane, Queensland, Australia.ORCID https://orcid.org/0000-0002-2895-0345
Murat AkovaSchool of Medicine, Department of Infectious Diseases and Clinical Microbiology, Hacettepe University, Ankara, Turkiye.ORCID https://orcid.org/0000-0002-6904-9473
David L PatersonADVANCE-ID, Saw Swee Hock School of Public Health, National University of Singapore, Singapore.ORCID https://orcid.org/0000-0003-2079-4437

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Asymptomatic bacteriuria (ASB) is generally systematically screened and treated with antibiotics in kidney transplant recipients (KTRs). We aimed to explore the role of antibiotic therapy in management of ASB in KTRs. Methods: Randomized controlled trials conducted through 10 May 2023 were searched on Ovid MEDLINE, Web of Science, PubMed, and Cochrane CENTRAL. We used inverse variance random-effects models for all meta-analyses; for rare outcomes, we used the Mantel-Haenszel method. ROB-2 criteria were used to assess the risk of bias. Results: We identified 4 randomized controlled trials (including 478 participants). Antibiotic therapy, compared with no therapy, nonsignificantly increased the risk of acute pyelonephritis by 19% (relative risk, 1.19 [95% confidence interval (CI)], .72-1.94; Conclusions: Current evidence does not support routine screening and treatment of posttransplant ASB in KTRs.

Indexed as

antibioticasymptomatic bacteriuriakidney transplantationpyelonephritisurinary tract infection

Identifiers

PMID41018707
PMCPMC12461846

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.