ArticleThe journal of allergy and clinical immunology. Global2025
Seasonal variation in respiratory syncytial virus-specific IgG concentrations in Northern Plains American Indian children with asthma.
Article in The journal of allergy and clinical immunology. Global, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Exposure to respiratory syncytial virus (RSV) during childhood is nearly ubiquitous by age 2 years, and infants who develop severe RSV bronchiolitis are more likely to develop asthma later in life. Objective: We sought to quantify IgG response to RSV infection in American Indian children with and without asthma and to investigate the environmental, clinical, and genetic factors that associate with varying response. Methods: We compared immunologic response to previous RSV infection in 319 children with and without asthma from a Northern Plains American Indian community and investigated the role of environmental and genetic factors in levels of RSV-specific IgG. Results: Overall, we found 73% of children to have high concentrations of RSV-specific IgG (>40 IU/mL), which was associated with the absence of asthma ( Conclusions: Our findings suggest a seasonal difference in immunologic response to RSV infection that varies by asthma status and warrants further investigation.
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