Evidence map›Paper›PMID 41018631›Full record

ArticleACS omega2025

Screening of Medicines for Malaria Venture Open Boxes Identifies Potent SARS-CoV‑2 Papain-like Protease (PL

Victor Oliveira Gawriljuk, Gabriela Dias Noske, Rafaela Sachetto Fernandes, Aline Minalli Nakamura, Marjorie C L C Freire, Mariana Ortiz Godoy, Vinicius Bonatto, Rafael Chelucci, Adriano Andricopulo, Malina A Bakowski and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Victor Oliveira GawriljukSão Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil.
Gabriela Dias NoskeSão Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil.
Rafaela Sachetto FernandesSão Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil.
Aline Minalli NakamuraSão Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil.
Marjorie C L C FreireSão Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil.ORCID https://orcid.org/0000-0001-7734-5144
Mariana Ortiz GodoySão Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil.
Vinicius BonattoSão Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil.
Rafael ChelucciSão Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil.ORCID https://orcid.org/0009-0008-4099-9986
Adriano AndricopuloSão Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil.ORCID https://orcid.org/0000-0002-0457-818X
Malina A BakowskiCalibr-Skaggs Institute for Innovative Medicine, La Jolla, California 92037, United States.
Karen C WolffCalibr-Skaggs Institute for Innovative Medicine, La Jolla, California 92037, United States.
Laura RivaCalibr-Skaggs Institute for Innovative Medicine, La Jolla, California 92037, United States.
Jeremy N BurrowsMMV Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, Geneva 1215, Switzerland.ORCID https://orcid.org/0000-0001-8448-6068
Timothy N C WellsMMV Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, Geneva 1215, Switzerland.
Benoît LaleuMMV Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, Geneva 1215, Switzerland.ORCID https://orcid.org/0000-0002-7530-2113
Ronaldo MartinsDepartment of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14040-900, Brazil.
Juliano Paula SouzaDepartment of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14040-900, Brazil.
Eurico ArrudaDepartment of Cellular and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14040-900, Brazil.
Kirandeep SambyJohnson and Johnson Pvt., Ltd., Gurgaon 122003, India.
Sujay LaskarTCG Lifesciences, West Bengal 700091, India.
Rafael Victorio Carvalho GuidoSão Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil.ORCID https://orcid.org/0000-0002-7187-0818
Glaucius OlivaSão Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil.
Andre Schutzer GodoySão Carlos Institute of Physics, University of São Paulo, Av. João Dagnone, 1100Jardim Santa Angelina, São Carlos 13563-120, Brazil.ORCID https://orcid.org/0000-0002-0613-9164

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic, caused by SARS-CoV-2, has led to more than 760 million infections and 6.9 million deaths worldwide. While vaccines have played a crucial role in controlling the disease, emerging viral variants pose a threat to their long-term efficacy, highlighting the need for antiviral therapies. To accelerate drug discovery, Medicines for Malaria Venture (MMV) developed open-access compound libraries, including the malaria box, pathogen box, COVID box and, with the drugs for neglected disease initiative, pandemic response box, comprising nearly 1400 drug-like molecules. These resources have been widely used in phenotypic screens to identify potential SARS-CoV-2 inhibitors, but target-based screening remained unexplored, especially for targets such as papain-like protease (PL

Identifiers

PMID41018631
PMCPMC12461331

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.