ArticleACS omega2025
DNA Origami-Based Luminescent Biosensors Enabling Smartphone Detection of Nucleic Acid Sequences.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Advances in DNA nanostructures for pathogenic microorganisms.Materials today. Bio · 2026Review
- A Programmable DNA Biohybrid Material Coupled with Intelligent Cell-Free Computation for Environmental Sensing.ACS omega · 2026Article
- From Blueprint to Breakthrough: How Far Can We Fold DNA Origami for Nano-Enabled Technologies?JACS Au · 2026Review
- Single-Molecule Detection Concepts Enabled by DNA Origami.Micromachines · 2026Review
- Comprehensive Review on DNA Hydrogels and DNA Origami-Enabled Wearable and Implantable Biosensors.Biosensors · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA origami enables the precise assembly of complex nanostructures, facilitating the visual detection of various molecular targets. Previously, we developed DNA origami-based nanosensors, termed "pliers", which allowed the detection of inorganic and organic single-molecule targets through shape transitions. However, these methods require costly analytical instruments, such as atomic force microscopy and fluorescence detection. To establish a more accessible and quantitative detection approach, we developed a luminescence-based DNA origami biosensor for nucleic acid detection. By redesigning the sensor module, we improved the structural stability and sensitivity. The integration of split luciferase enabled signal amplification proportional to the target RNA concentration, allowing for precise detection using a smartphone. Additionally, combining this method with PCR successfully detected as few as 100 copies of
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.