Hyaluronic Acid Immersion Enhances Gamma-Ray-Irradiation Cross-Linking of the Fish-Derived Type I Collagen Membrane.

Vincent Irawan, Ryoma Furusho, Yoshihiro Kodama, Yuta Aida, Hayato Laurence Mizuno, Yasutaka Anraku, Toshiyuki Ikoma

Abstract read

In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vincent IrawanChair of Bioseparation Engineering, TUM School of Engineering and Design, Technical University of Munich, Boltzmannstr. 15, 85748 Garching, Germany.ORCID https://orcid.org/0009-0005-8559-4163

Ryoma FurushoDepartment of Materials Science and Engineering, School of Materials and Chemical Technology, Institute of Science Tokyo, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan.

Yoshihiro KodamaTaki Chemical Co., Ltd., 346 Miyanishi, Harima-cho, Kako-gun, Hyogo 675-0145, Japan.

Yuta AidaDepartment of Materials Science and Engineering, School of Materials and Chemical Technology, Institute of Science Tokyo, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan.

Hayato Laurence MizunoDepartment of Materials Science and Engineering, School of Materials and Chemical Technology, Institute of Science Tokyo, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan.

Yasutaka AnrakuDepartment of Materials Science and Engineering, School of Materials and Chemical Technology, Institute of Science Tokyo, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan.ORCID https://orcid.org/0000-0002-0764-1463

Toshiyuki IkomaDepartment of Materials Science and Engineering, School of Materials and Chemical Technology, Institute of Science Tokyo, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan.ORCID https://orcid.org/0000-0003-3154-1777

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fish-derived type I collagen is widely used in biomedical implants; however, its limited thermal and enzymatic stability necessitates cross-linking for clinical applications. This study investigated gamma-ray-induced cross-linking of collagen as a shape of membranes, with enhancement via polysaccharide-assisted immersion. Hydrated collagen membranes were irradiated at doses ranging from 15 kDa to 35 kGy to assess their dose-dependent effects. Irradiation at 15 kGy enhanced thermal and enzymatic stability, which declined at higher doses. To further enhance stability, the membranes were immersed in phosphate-buffered saline containing chondroitin sulfate (CS) or hyaluronic acid (HA) during irradiation at 25 kGy. HA-treated membranes showed a synergistic enhancement in thermal stability (

Identifiers

PMID41018581

DOI10.1021/acsomega.5c07582

PMCPMC12461391

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