ArticleCureus2025
Trial Designs Beyond Traditional Randomized Controlled Trials: Applications and Appropriateness in Osteoarthritis Research.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of osteoarthritis (OA) has been rising, and despite the many years of scientific research and evidence collection, OA remains a medical issue where effective interventions are limited due to the complexity and heterogeneity of the disease, the disconnect between symptoms and structural changes, and potential demands from an authoritative standpoint. Though randomized controlled trials (RCTs) are considered the gold standard in research, they might not be as applicable in the context of OA research. Hence, this editorial aims to investigate alternative trial designs and highlight the strengths and limitations of their utilization to develop effective interventions and treatments, which may ultimately lower the OA burden and improve patient outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.