SynthesisFrontiers in neurology2025
Efficacy of hyperbaric oxygen therapy in postoperative patients with cerebral aneurysms: a systematic review and meta-analysis.
Synthesis in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Background: Surgical management of intracranial aneurysms frequently results in postoperative neurological impairments and diminished quality of life. Hyperbaric Oxygen Therapy (HBOT) has emerged as a potential adjunctive treatment to enhance neurological recovery and functional outcomes; however, its effectiveness remains debated. Objective: This systematic review and meta-analysis aimed to assess the efficacy of HBOT on clinical outcomes, neurological improvement, functional independence, and health-related quality of life in postoperative intracranial aneurysm patients. Methods: Randomized controlled trials (RCTs) comparing HBOT combined with routine postoperative care versus routine care alone were identified through comprehensive database searches of PubMed, Web of Science, CNKI, Wanfang, and VIP up to April 2025. Data were analyzed using fixed- or random-effects models based on heterogeneity. Risk ratios (RR) and standardized mean differences (SMD), with corresponding 95% confidence intervals (CI), were calculated as summary measures. Results: A total of 11 RCTs, encompassing 2,268 patients, were analyzed. HBOT significantly improved clinical treatment efficacy (RR = 1.19, 95% CI: 1.11-1.28, Conclusion: Adjunctive hyperbaric oxygen therapy significantly enhances neurological recovery, functional outcomes, and overall quality of life in patients following intracranial aneurysm surgery. These results advocate for the clinical adoption of HBOT; nevertheless, additional high-quality, multicenter studies are necessary to confirm sustained long-term effects. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251086811.
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