Evidence map›Paper›PMID 41018133›Full record

Trial reportInternational journal of women's health2025

Vaginal Lactobacillus Alteration and Vaginal Symptom Relief After Carbon Dioxide Vaginal Laser Therapy in Postmenopausal Women.

Teerapan Seehanantawong, Pisut Pongchaikul, Rujira Wattanayingcharoenchai, Komkrit Aimjirakul, Orawee Chinthakanan, Pitak Santanirand, Jittima Manonai

Abstract readCase ReportsClinical Trial
In one paragraph

Trial report in International journal of women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Teerapan SeehanantawongDepartment of Obstetrics & Gynaecology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Pisut PongchaikulRamathibodi Medical School, Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Rujira WattanayingcharoenchaiDepartment of Obstetrics & Gynaecology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Komkrit AimjirakulDepartment of Obstetrics & Gynaecology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Orawee ChinthakananDepartment of Obstetrics & Gynaecology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Pitak SantanirandDepartment of Microbiology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Jittima ManonaiDepartment of Obstetrics & Gynaecology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To assess changes in the prevalence and abundance of vaginal Lactobacillus after fractional micro-ablative carbon dioxide (CO Methods: This prospective, single-arm clinical study was conducted in postmenopausal women who underwent treatment with CO Results: Forty-three postmenopausal women with at least one symptom of VVA, with a mean age of 67.3 ± 8.7 years, were recruited. The mean Nugent scores for Lactobacillus morphotypes gradually decreased from 2.84 (95% CI: 2.38-3.29) at baseline to 2.28 (95% CI: 1.79-2.77) at week 8, 2.09 (95% CI: 1.60-2.58) at week 20, and further to 1.84 (95% CI: 1.31-2.35) at week 32 (p < 0.05). The prevalence of Lactobacillus increased from 27.9% (12/43) at baseline to 48.8% (21/43) at week 8, 55.8% (24/43) at week 20, and 58.1% (25/43) at week 32 (p < 0.05). VVA symptom severity and vaginal pH consistently declined from baseline to week 32 (p < 0.05). Conclusion: Fractional CO

Indexed as

CO2 laser therapygenitourinary syndrome of menopauseLactobacilluspostmenopausal womenvaginal microbiotavulvovaginal atrophy

Identifiers

PMID41018133
PMCPMC12466563

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.