ArticleJournal of cancer science and clinical therapeutics2025
CAR T-Cell Therapy in Cancer: Balancing Efficacy with Cardiac Toxicity Concerns.
Article in Journal of cancer science and clinical therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Stiff Person Syndrome: Bridging Neuroimmunology and Rehabilitation for Improved Patient Outcomes.Archives of internal medicine research · 2026Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
CAR-T therapy (Chimeric antigen receptor T-cell therapy) is a novel and transformative approach to fighting cancer, modulating the immune system involving adoptive cell therapy. In this article, a comprehensive information is provided on the effectiveness of CAR-T therapy in various types of cancers some of which have shown to be particularly challenging cancers to fully eliminate. The clinical effectiveness of CAR-T therapy compared to other traditional methods of cancer treatments such as surgical, radiotherapy, high dose rate (HDR)-brachytherapy, and immunotherapy favors CAR-T cell treatment strategy. The article presents the concept of CAR-T, discuss the structure and function of this novel therapeutic and its efficacy in liquid cancers, and development of therapies in solid cancers. Partial and complete response rates in relation to the CAR-T methodologies on various cancers are critically reviewed with discussion on the durability and overall long-term effects and limitations. Potential role of CAR-T therapies in various cancer treatments is reviewed in conjunction with other therapies and the efficacies and status on the progress of those therapies. Despite the impressive efficacy of CAR-T therapy, it is associated with potentially serious side effects, particularly cardiovascular toxicities that require proper cardiovascular screening prior, during, and after CAR-T therapy. These highlight the standardized modes of monitoring, prevention, and management of the toxicities. The cytokine release storm (CRS) in the pathogenesis of CAR-T toxicities may manifest in different ways emphasizing heterogeneous clinical presentation of CAR-T adverse events, highlighting the need for vigilant monitoring and individualized management strategies. Nonetheless, additional information on the serious adverse effects and long-term effects warrants further investigation.
Indexed as
Identifiers
41018125PMC12470419What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.