Trial reportJournal of biomedical optics2025
3D photogrammetry quantifies the size of basal cell carcinoma lesions with submillimeter accuracy: high correlation with lesion response to photodynamic therapy.
Trial report in Journal of biomedical optics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
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Abstract
Significance: Noninvasive imaging to accurately measure subtle changes in tumor size is underutilized when assessing therapeutic responses in the skin. During photodynamic therapy (PDT) for basal cell carcinoma (BCC), a better definition of the tumor size threshold for PDT responsiveness is needed. Aim: We aim to quantitatively demonstrate the first clinical evidence of tumor shrinkage after multiple rounds of PDT using a robust measurement and analysis approach. Approach: Tumors were monitored experimentally using a 3D camera and software system (stereo photogrammetry). A total of 122 BCC tumors in 35 patients were treated with PDT (5-ALA and blue light) in three sessions. Calculated volumes and heights were used to plot changes in tumor size. Results: In total, 70% of BCC cleared completely. Measured heights correlated with histological tumor depth; average heights were Conclusions: 3D photogrammetry can inform the selection of BCC tumors for PDT with exceptionally high spatial accuracy, dramatically better than can be quantified by a clinician.
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