ArticleFrontiers in pediatrics2025
Comparison of the vitamin D level between children with and without cow's milk protein allergy: a systematic review with meta-analysis.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of vitamin D levels and vitamin D supplementation on allergic diseases: an umbrella review.Frontiers in allergy · 2026Pooled it
- A Systematic Review of the Correlation Between Micronutrient Levels and Perinatal Depression.Nutrients · 2025Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Vitamin D plays an important role in modulating immune responses, which may be associated with cow's milk protein allergy (CMPA). This meta-analysis aimed to comprehensively compare the vitamin D level between children with CMPA and healthy controls. Methods: Studies comparing the vitamin D level between children with CMPA and healthy controls were comprehensively searched in PubMed, Web of Science, Embase, Wan Fang, CNKI, and VIP until April 2025. Results: A total of 12 studies, involving 605 children with confirmed CMPA (CMPA group) and 558 healthy controls (control group) were included. The vitamin D level was lower in the CMPA group than in the control group [standardized mean difference (SMD) (95% confidence interval): -1.229 (-2.117, -0.340), Conclusion: Vitamin D is decreased in children with CMPA, indicating its potential association with CMPA. These findings may enhance the understanding of CMPA and guide the prevention or management of CMPA in children.
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Registered trials
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