Evidence map›Paper›PMID 41018018›Full record

ArticleFrontiers in physiology2025

Lung uptake of two SPECT markers identifies sensitivity to hyperoxia-induced acute respiratory distress syndrome in rats.

Anne V Clough, Pardis Taheri, Guru P Sharma, Ming Zhao, Elizabeth R Jacobs, Said H Audi

Abstract read
In one paragraph

Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anne V CloughDepartment of Mathematical and Statistical Sciences, Marquette University, Milwaukee, WI, United States.
Pardis TaheriJoint Department of Biomedical Engineering, Medical College of Wisconsin, Marquette University, Milwaukee, WI, United States.
Guru P SharmaDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, United States.
Ming ZhaoDepartment of Medicine (Cardiology), Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Elizabeth R JacobsDepartment of Medicine (Pulmonary), Medical College of Wisconsin, Milwaukee, WI, United States.
Said H AudiJoint Department of Biomedical Engineering, Medical College of Wisconsin, Marquette University, Milwaukee, WI, United States.

Funding

SPECT Imaging and Computational Modeling for Assessment of Acute Lung InjuryR15HL129209 · NHLBI · MARQUETTE UNIVERSITY · PI SAID H AUDI · 2015 to 2026
$1.8M
NHLBI NIH HHS R15 HL129209
6 · The paper itself

Abstract

Introduction: Exposure of adult rats to hyperoxia is a well-established model of human Acute Respiratory Distress Syndrome (ARDS). Although rats exposed to 100% O Methods: Sprague-Dawley rats were exposed to either room air (normoxia), >95% O Results: Discussion: Overall, these results suggest the potential utility of

Indexed as

ARDSglutathioneHMPAOmolecular imagingsingle photon emission computedtomography (SPECT)

Identifiers

PMID41018018
PMCPMC12463966

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.