ArticlemedRxiv : the preprint server for health sciences2025
Panorama of Chromosomal Instability in Lung Cancer.
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Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1citing papers in PubMed
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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1 citing paper in PubMed.
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Authors and funding
64 authors.
Yang YangBen May Department for Cancer Research, University of Chicago, Chicago, IL, USA.
Xiaoming ZhongBen May Department for Cancer Research, University of Chicago, Chicago, IL, USA.
William PhillipsBen May Department for Cancer Research, University of Chicago, Chicago, IL, USA.
Wei ZhaoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Phuc H HoangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Christopher WirthManchester Cancer Research Centre, Division of Cancer Sciences, University of Manchester, Manchester, UK.
Soo-Ryum YangDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Charles LeducDepartment of Pathology, Centre Hospitalier de l'Université de Montréal, Montreal, Canada.
Marina K BaineDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
William D TravisDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Lynette M ShollDepartment of Pathology, Brigham and Women's Hospital, Boston, MA.
Philippe JoubertInstitut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec City, Canada, Université Laval, Laval, Québec, Canada.
Robert HomerDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA.
Jian SangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Azhar KhandekarDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
John P McElderryDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Thi-Van-Trinh TranDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Caleb HartmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Mona MiraftabDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Monjoy SahaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Olivia W LeeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Sunandini SharmaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Kristine M JonesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Bin ZhuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Marcos Díaz-GayDigital Genomics Group, Cancer Genomics Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain.
Eric S EdellDivision of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Jacobo Martínez SantamaríaBiobanco IBSP-CV FISABIO Red Valenciana de Biobancos, Cataluña, Valencia.
Matthew B SchabathDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Sai S YendamuriThoracic Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Marta ManczukDepartment of Cancer Epidemiology and Primary Prevention, Maria Skłodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
Jolanta LissowskaDepartment of Cancer Epidemiology and Primary Prevention, Maria Skłodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
Beata ŚwiątkowskaDepartment of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Łódź, Poland.
Anush MukeriaDepartment of Clinical Epidemiology, N.N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia.
Oxana ShanginaDepartment of Clinical Epidemiology, N.N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia.
David ZaridzeDepartment of Clinical Epidemiology, N.N. Blokhin National Medical Research Centre of Oncology, Moscow, Russia.
Ivana HolcatovaInstitute of Public Health & Preventive Medicine, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic.
Vladimir JanoutFaculty of Health Sciences, Palacky University, Olomouc, Czech Republic.
Dana MatesDepartment of Occupational Health and Toxicology, National Center for Environmental Risk Monitoring, National Institute of Public Health, Bucharest, Romania.
Simona OgnjanovicInternational Organisation for Cancer Prevention and Research (IOCPR), Belgrade, Serbia.
Milan SavicDepartment of Thoracic Surgery, Clinical Center of Serbia, Belgrade, Serbia.
Milica KonticClinic of Pulmonology, University Clinical Center of Serbia, Belgrade. School of Medicine, University of Belgrade.
Yohan BosséInstitut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Quebec City, Canada, Université Laval, Laval, Québec, Canada.
Bonnie E Gould RothbergSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, USA.
David C ChristianiDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Valerie GaborieauGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Paul BrennanGenomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Geoffrey LiuDivision of Medical Oncology, Medicine, Princess Margaret Cancer Centre, Temerty Faculty of Medicine, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Paul HofmanNice University Hospital Centre (Nice UHC) - University Côte d'Azur and the Nice Biobank CRB, Nice, France.
Maria Pik WongQueen Mary Hospital, The University of Hong Kong, Hong Kong, China.
Kin Chung LeungDepartment of Pathology, The University of Hong Kong, Hong Kong, China.
Chih-Yi ChenInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Chao Agnes HsiungInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Angela C PesatoriDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Dario ConsonniFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Qing LanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Martin A NowakDepartment of Mathematics, Harvard University, Cambridge, Massachusetts, USA.
David C WedgeManchester Cancer Research Centre, Division of Cancer Sciences, University of Manchester, Manchester, UK.
Ludmil B AlexandrovDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Jianxin ShiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Tongwu ZhangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Lixing YangBen May Department for Cancer Research, University of Chicago, Chicago, IL, USA.
Maria Teresa LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Funding
TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI John L. Cleveland · 1998 to 2026
$93.5MStudies of Genetic and Environmental EpidemiologyZIACP101231 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI LANDI, MARIA · 2018 to 2025
$23.6MUnveiling non-coding drivers of cancerR01CA269977 · NCI · UNIVERSITY OF CHICAGO · PI Lixing Yang · 2022 to 2026
$2.2MIntramural NIH HHS ZIA CP101231NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA269977
Abstract
Lung cancer is a highly heterogeneous disease primarily driven by tobacco smoking. About 20% of lung cancers occur among patients who have never smoked (LCINS) with differences in patient ancestry, sex, tumor histology, and clinical features. Our understanding of chromosomal instability in lung cancer, especially LCINS, is still limited. Here, we perform a comprehensive study of 182,429 somatic structural variations (SVs) detected in 1,209 whole-genome sequenced lung cancers, of which 864 LCINS. SVs are more abundant in tumors from patients who have smoked (LCSS); however, they are more complex and play more important roles in tumorigenesis in LCINS.
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