Evidence map›Paper›PMID 41018000›Full record

ArticleEnvironmental science & technology letters2025

Phenotypic Profiling of 6PPD, 6PPD-quinone and Structurally Diverse Antiozonants in RTgill-W1 Cells Using the Cell Painting Assay.

Felix R Harris, Mark D Jankowski, Daniel L Villeneuve, Joshua A Harrill

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental science & technology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. 6PPD and 6PPD-Q Induce Mitochondrial Dysfunction inInternational journal of molecular sciences · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Felix R HarrisU.S. EPA, Office of Research and Development, Center for Computational Toxicology and Exposure, Biomolecular and Computational Toxicology Division, Research Triangle Park, NC 27711, United States.
Mark D JankowskiU.S. EPA, Region 10, Laboratory Services and Applied Science Division, Seattle, WA 98101, United States.
Daniel L VilleneuveU.S. EPA, Office of Research and Development, Center for Computational Toxicology and Exposure, Great Lakes Toxicology and Ecology Division, Duluth, MN 55804, United States.
Joshua A HarrillU.S. EPA, Office of Research and Development, Center for Computational Toxicology and Exposure, Biomolecular and Computational Toxicology Division, Research Triangle Park, NC 27711, United States.

Funding

Intramural EPA EPA999999
6 · The paper itself

Abstract

6PPD-quinone, a degradation product of the rubber antiozonant 6PPD that is frequently added to tires, has previously been identified as a causative agent of urban runoff mortality syndrome in salmonids. Previous high-throughput phenotypic profiling (HTPP) studies using the Cell Painting assay in the RTgill-W1 rainbow trout cell line has demonstrated that 6PPD-quinone toxicity occurs at much lower concentrations than the 6PPD parent molecule, which is consistent with available

Indexed as

6PPD-quinoneCell Paintingecotoxicologyin vitro toxicologyp-phenylenediaminesRTgill-W1 cells

Identifiers

PMID41018000
PMCPMC12466415

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.