ArticleJournal of oral biology and craniofacial research
Biomechanical analysis of mandibular cartilage defect regeneration after implantation of human umbilical cord mesenchymal stem cells and a platelet rich fibrin scaffold: an experimental animal study.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Background: Regenerative medicine is therapy that is expected to be effective for mandibular cartilage defect regeneration. Nevertheless, the biomechanical aspects of mandibular condyle cartilage defect regeneration are still rarely discussed. Objective: This study aimed too analyze the compression, tensile, shear strength, and elastic modulus in the mandibular condyle cartilage defect regeneration in an animal model after the implantation of Results: The hUCMSC group had a higher strength of compression (13,462 ± 0,889) MPa with a significant difference (p = 0,000) and tensile strength (2723 ± 0,985) MPa with a significant difference (p = 0,003) than the other groups. The average shear strength and elastic modulus showed that the hUCMSC (1162 ± 0,090 and 8700 ± 1502) and combination groups (0,728 ± 0,071 and 7742 ± 0,814) have significantly higher values than the other groups (p = 0,014 and p = 0,000). Conclusion: The implantation of hUCMSC results in a high compression and tensile strength of the regenerated defect. The implantation of hUCMSC or hUCMSC seeded on a PRF scaffold is a novel method for mandible cartilage regeneration, and they showed better biomechanics in shear strength and elastic modulus.
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