ReviewIndian journal of psychological medicine2025
Morphological Changes of the Retina in Alcohol Use Disorder: A Systematic Review and Meta-analysis of Studies Using Optical Coherence Tomography.
Review in Indian journal of psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Translation and adaptation of the Brief Intervention Adherence Scale for the Tanzanian culture.Global mental health (Cambridge, England) · 2026Article
- Ethanol and Cyanide: A Case Report on Toxic and Nutritional Optic Neuropathy Associated With Alcohol and Tobacco.Cureus · 2025Article
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Authors and funding
7 authors.
Funding
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Abstract
Purpose of the Review: Chronic alcohol use is associated with various structural and functional changes in the brain. Retinal morphology assessed by optical coherence tomography (OCT) non-invasively detects alcohol related damage to the brain and can be a disease marker. Collection and Analysis of Data: A systematic review of studies comparing retinal morphology using OCT, between alcohol use disorder (AUD) patients and healthy controls (HC) from PubMed, Scopus and Embase databases was performed (on 15/April/2025). Random effects meta-analyses were conducted for the thickness of retinal parameters, at both disc and macula: Retinal nerve fibre layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), ganglion cell-inner plexiform layer (GCIPL), choroid thickness (CT), macular thickness (MT) and macular volume (MV). The Newcastle-Ottawa Scale was used for risk of bias (RoB) assessment. Publication bias, sensitivity analysis and certainty of evidence (CoE) was assessed using Doi plots, the leave-one-out method and the GRADE approach, respectively. Results: Of the 2,416 records screened, eight studies ( Conclusions: Evidence for thinning of retinal layers, especially the peripapillary RNFL, as AUD disease-markers is promising, but preliminary. Our results align with the hypothesis that chronic alcohol consumption induces neurodegenerative changes in the retina and, therefore, the brain.
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