Evidence map›Paper›PMID 41017914›Full record

ArticleFrontiers in cellular and infection microbiology2025

BALB/c mice infection with hybrid

Ana Carolina Stocco Lima, Thaise Yumie Tomokane, Gabriela Fernandes Rodrigues, Larissa Dos Santos Alcântara, Marliane Batista Campos, Maíra Pombo, Márcia Dalastra Laurenti, Vania Lucia Ribeiro da Matta, Lucile Maria Floeter-Winter, Carlos Eduardo Pereira Corbett and 2 more

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ana Carolina Stocco Lima *Laboratório de Patologia de Moléstias Infecciosas (LIM50), Departamento de Patologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
Thaise Yumie Tomokane *Laboratório de Patologia de Moléstias Infecciosas (LIM50), Departamento de Patologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
Gabriela Fernandes RodriguesLaboratório de Patologia de Moléstias Infecciosas (LIM50), Departamento de Patologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
Larissa Dos Santos AlcântaraLaboratório de Patologia de Moléstias Infecciosas (LIM50), Departamento de Patologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
Marliane Batista CamposMinistério da Saúde, Secretaria de Vigilância em Saúde, Instituto Evandro Chagas, Seção de Parasitologia, Ananindeua, PA, Brazil.
Maíra PomboDepartamento de Ciências Biológicas e da Saúde, Universidade Federal do Amapá, Macapá, Amapá, Brazil.
Márcia Dalastra LaurentiLaboratório de Patologia de Moléstias Infecciosas (LIM50), Departamento de Patologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
Vania Lucia Ribeiro da MattaLaboratório de Patologia de Moléstias Infecciosas (LIM50), Departamento de Patologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
Lucile Maria Floeter-WinterInstituto de Biociências, Universidade de São Paulo, São Paulo, SP, Brazil.
Carlos Eduardo Pereira CorbettLaboratório de Patologia de Moléstias Infecciosas (LIM50), Departamento de Patologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
Fernando Tobias SilveiraMinistério da Saúde, Secretaria de Vigilância em Saúde, Instituto Evandro Chagas, Seção de Parasitologia, Ananindeua, PA, Brazil.
Cláudia Maria de Castro GomesLaboratório de Patologia de Moléstias Infecciosas (LIM50), Departamento de Patologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Hybridization events within the genus Methods: Balb/c mice were inoculated with stationary-phase promastigote forms of each parasite. Lesion development and parasite load were monitored longitudinally, and cytokine production was assessed at 35 days post-infection (PI). Results: The infection with the hybrid parasite induced a more rapid and evident progression, attaining its largest dimension between days 14 and 28 days PI, followed by regression. In contrast, infection with Discussion: The immunologic response of hybrid parasite infection was associated with reduced gamma interferon (IFN-γ) and elevated interleukin 4 (IL-4) production compared to parental species and controls (P < 0.05), with no significant differences observed in interleukin 12 (IL-12p40) or interleukin 10 (IL-10). Infection with Conclusion: Together, these findings provide important insights into the distinct biological behavior of the

Indexed as

Hybridization, GeneticLeishmaniaLeishmania guyanensisLeishmaniasisLeishmaniasis, CutaneousAnimalsCytokinesDisease Models, AnimalFemaleInterleukin-4Lymph NodesMiceMice, Inbred BALB CParasite LoadSkinVirulenceCytokinesInterleukin-4biological behaviorcutaneous leishmaniasishybrid parasiteL. (V.) guyanensisL. (V.) shawi

Identifiers

PMID41017914
PMCPMC12460293

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.