Evidence map›Paper›PMID 41017900›Full record

ArticleInterface focus2025

Including frameworks of public health ethics in computational modelling of infectious disease interventions.

Alex Zarebski, Nefel Tellioglu, Jessica Stockdale, Julie A Spencer, Wasiur R KhudaBukhsh, Joel Miller, Cameron Zachreson

Abstract read
In one paragraph

Article in Interface focus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alex Zarebski *University of Melbourne School of Mathematics and Statistics, Parkville, Victoria, Australia.
Nefel Tellioglu *Department of Infectious Diseases, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Jessica StockdaleDepartment of Mathematics, Simon Fraser University, Burnaby, Canada.ORCID https://orcid.org/0000-0001-7984-1010
Julie A SpencerInformation Systems and Modeling Group, Los Alamos National Laboratory, Los Alamos, NM, USA.ORCID https://orcid.org/0000-0001-8756-6987
Wasiur R KhudaBukhshSchool of Mathematical Sciences, University of Nottingham, Nottingham, UK.
Joel MillerDepartment of Mathematical and Physical Sciences, La Trobe University, Melbourne, Australia.
Cameron ZachresonThe University of Melbourne School of Computing and Information Systems, Parkville, Victoria, Australia.ORCID https://orcid.org/0000-0002-0578-4049

Funding

Wellcome Trust
6 · The paper itself

Abstract

Decisions on public health interventions to control infectious diseases are often informed by computational models. Interpreting the predicted outcomes of a public health decision requires not only high-quality modelling but also an ethical framework for assessing the benefits and harms associated with different options. The design and specification of ethical frameworks matured independently of computational modelling, so many values recognized as important for ethical decision-making are missing from computational models. We demonstrate a proof-of-concept approach to incorporate multiple public health values into the evaluation of a simple computational model for vaccination against a pathogen such as SARS-CoV-2. By examining a bounded space of alternative prioritizations of three values relevant to public health ethics (aggregate clinical burden, equity in clinical burden, equity in adverse effects from vaccination), we identify value trade-offs, where the outcomes of optimal strategies differ depending on the ethical framework. This work demonstrates an approach to incorporating diverse values into decision criteria used to evaluate outcomes of models of infectious disease interventions.

Indexed as

computational modelethical frameworkinfectious diseaseinterventionpublic health ethicsvaccination

Identifiers

PMID41017900
PMCPMC12464577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.