ReviewComputational and structural biotechnology journal2025
Epigenetic memory: The role of the crosstalk between histone modifications and DNA methylation.
Review in Computational and structural biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Beyond The Nucleus: Translating Engineered Protein Localization To Chromatin Modifying Enzymes.Current opinion in biomedical engineering · 2026Article
- Epigenetic regulation in cancer metastasis.Discover oncology · 2026Review
- Article
- The microbiome-gerogene axis: a new frontier in precision geromedicine.Frontiers in aging · 2026Review
- Integrating Plant Physiology and Microbiome Engineering for Climate-Resilient Crops: Bridging Knowledge Gaps in Multi-Stress Tolerance.Physiologia plantarumReview
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epigenetic memory allows different cells to maintain distinct gene expression patterns despite a common genetic code and plays a role in several biological processes. Chemical modifications to DNA and histones have appeared as critical mediators of epigenetic memory and much attention has gone into characterizing their dynamics. The network of positive feedback loops that these modifications form generates a rich set of dynamics that both recapitulate the traditional binary memory paradigm and also predict a new form of memory that we call analog memory. In this paper, we review models of chromatin modifications and describe how binary or analog memory hinge on the presence or lack of positive feedback loops between repressive histone modifications and DNA methylation. Future research using advanced genetic engineering tools will be able to validate the molecular interactions that dictate different forms of memory, and will thus deepen our understanding of how epigenetic memories form in different biological contexts.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.