Evidence map›Paper›PMID 41017820›Full record

ReviewTheScientificWorldJournal2025

The Role of BSL-3 Laboratories in Pandemic Preparedness: A Focus on Brazil's Infrastructure for Biosafety and Disease Control.

Roni Vinhas, Fabricia Oliveira, Larissa Fonseca, Katharine Hodel, Claudio Mafra, Cíntia Minafra, Marilda Gonçalves, Bruna Machado

Abstract readReview
In one paragraph

Review in TheScientificWorldJournal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Roni VinhasGonçalo Moniz Institute (IGM) Oswaldo Cruz Foundation (Fiocruz), Salvador, Brazil.ORCID https://orcid.org/0009-0006-0545-2446
Fabricia OliveiraSENAI Institute for Advanced Health Systems SENAI/CIMATEC University Center, Salvador, Brazil.ORCID https://orcid.org/0000-0003-4241-5768
Larissa FonsecaGonçalo Moniz Institute (IGM) Oswaldo Cruz Foundation (Fiocruz), Salvador, Brazil.ORCID https://orcid.org/0000-0003-4405-1582
Katharine HodelSENAI Institute for Advanced Health Systems SENAI/CIMATEC University Center, Salvador, Brazil.ORCID https://orcid.org/0000-0001-7898-6672
Claudio MafraCenter for Biological and Health Sciences, Department of Biochemistry and Molecular Biology, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0003-0101-4212
Cíntia MinafraSchool of Veterinary and Animal Science, Federal University of Goiás, Goiânia, Brazil.ORCID https://orcid.org/0000-0002-0727-5651
Marilda GonçalvesGonçalo Moniz Institute (IGM) Oswaldo Cruz Foundation (Fiocruz), Salvador, Brazil.ORCID https://orcid.org/0000-0003-3000-1437
Bruna MachadoSENAI CIMATEC University Center, Salvador, Brazil.ORCID https://orcid.org/0000-0003-1655-0325

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BSL-3 laboratories are fundamental for the safe handling of infectious microorganisms that require high-containment measures. Through a literature review, this work was aimed at highlighting the importance of these laboratories in supporting research and public health responses, especially during health emergencies. The review presents an overview of the global distribution of BSL-3 facilities, the impacts of the COVID-19 pandemic on laboratory investments, and future perspectives on their role in national development. It was observed that the pandemic exposed limitations in laboratory capacity, leading many countries to operate in suboptimal environments, underscoring the need for strict biosafety standards and preparedness infrastructure. This review also identifies disparities in global BSL-3 capacity-particularly in low- and middle-income countries-and examines the Brazilian context, where the absence of a unified regulatory framework hinders progress. By synthesizing international trends and Brazil's recent initiatives, including the development of its first BSL-4 laboratory, this work contributes to understanding the challenges and opportunities for strengthening biosafety infrastructure in support of equitable pandemic preparedness.

Indexed as

Containment of BiohazardsCOVID-19LaboratoriesPandemicsBrazilHumansPandemic PreparednessSARS-CoV-2biosafetyBSL-3 laboratoriesCOVID-19health surveillancepandemicpublic health

Identifiers

PMID41017820
PMCPMC12463526

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.