Evidence map›Paper›PMID 41017725›Full record

ArticleNeural regeneration research2026

Engineered mesenchymal stem cell-derived extracellular vesicles overexpressing miR-146a alleviate neuroinflammation in Alzheimer's disease.

Jia Zhang, Siqi He, Qiguo Xiao, Weijie Jiang, Bo Wang, Jing Lu, Hongfeng Gu, Yajin Liao, Zhi Wang, Ying Xu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Extracellular vesicle-based therapies for neurodegenerative diseases.NeuroImmune pharmacology and therapeutics · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jia ZhangThe Second Affiliated Hospital, University of South China, Hengyang, Hunan Province, China.
Siqi HeThe Second Affiliated Hospital, University of South China, Hengyang, Hunan Province, China.
Qiguo XiaoThe Second Affiliated Hospital, University of South China, Hengyang, Hunan Province, China.
Weijie JiangThe Second Affiliated Hospital, University of South China, Hengyang, Hunan Province, China.
Bo WangDepartment of Physiology & Key Laboratory of Hunan Province for Major Brain Diseases, Hengyang Medical School, University of South China, Hengyang, Hunan Province, China.
Jing LuThe Second Affiliated Hospital, University of South China, Hengyang, Hunan Province, China.
Hongfeng GuDepartment of Physiology & Key Laboratory of Hunan Province for Major Brain Diseases, Hengyang Medical School, University of South China, Hengyang, Hunan Province, China.
Yajin LiaoThe Second Affiliated Hospital, University of South China, Hengyang, Hunan Province, China.
Zhi WangThe Second Affiliated Hospital, University of South China, Hengyang, Hunan Province, China.
Ying XuGuangdong-Hong Kong-Macau Institute of Central Nervous System Regeneration, Key Laboratory of Central Nervous System Regeneration, Ministry of Education, Jinan University, Guangzhou, Guangdong Province, China.
Dan WangDepartment of Pathology, Beihua University, Jilin, Jilin Province, China.ORCID 0000-0001-7756-7104
Xiaoqing TangThe Second Affiliated Hospital, University of South China, Hengyang, Hunan Province, China.ORCID 0000-0002-3518-9275
Ling QiDivision of Gastroenterology, Institute of Digestive Disease, the Affiliated Qingyuan Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, Guangdong Province, China.ORCID 0000-0002-6275-3599

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer’s diseaseamyloid-βcognitive functionmesenchymal stem cell–derived extracellular vesiclesmicrogliamiR-146aneuroinflammationneuroprotectionnuclear factor-κBnuclear receptor subfamily 4 group A member 3 (NR4A3)

Identifiers

PMID41017725
PMCPMC13568608

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.