ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025
Ptgs2+ CPTC Function as a "Force-Immune Axis" by Responding to Acupuncture and Mediating M2 Macrophage Activation for Anti-Inflammatory Effects.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The trial behind it
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Who cites it
5 citing papers in PubMed.
- CPTCs Drive Somatic-Visceral Communication via the Wnt Axis in Somatic Mechanotherapy: A Single-Cell Deep Learning Study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- In Situ Construction of Fascial Analogues Induced by Low-Growth-Factor Matrigel.Animals : an open access journal from MDPI · 2026Article
- Telocytes Twenty Years on: A Critical Reappraisal of Identity, Function, and Pathological Relevance.International journal of molecular sciences · 2026Review
- Bridging physics and biology in acupuncture: flexible multimodal bioelectronics for decoding the deqi microenvironment.Frontiers in bioengineering and biotechnology · 2026Review
- Ptgs2+ CPTC Function as a "Force-Immune Axis" by Responding to Acupuncture and Mediating M2 Macrophage Activation for Anti-Inflammatory Effects.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Recent advancements have highlighted the imperative for cytological exploration of fascial tissues. Telocytes, specialized interstitial cells found in connective tissues such as fascia, have garnered significant attention. Our study explored the cellular landscape of the abdominal midline fascia (AMF), revealing a primary presence of Cd34+/Pdgfra+ telocytes (CPTCs) by single-cell sequencing and cytomorphology. We identified six CPTC subpopulations with deep learning, notably Ptgs2+ CPTCs, which exhibited remarkable responsiveness to mechanical stimulus. Following the acupuncture stimulation at the special acupoints along the AMF in dysenteric rats, the proportion of Ptgs2+ CPTCs increased significantly, with these cells exhibiting strengthened cell adhesion with all CPTC subpopulations. Importantly, Ptgs2+ CPTCs activated M2 macrophages through the Il6-Il6st-Stat3 pathway, promoting anti-inflammatory responses. For the first time, our findings established Ptgs2+ CPTCs as a key "force-immune axis" that linked mechanical stimulation and immune modulation, advancing our understanding of the cellular mechanisms behind acupuncture and its potential to modulate inflammation in immune-related disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.