Evidence map›Paper›PMID 41017561›Full record

ArticleVirulence2025

EefR mutations drive sanguinarine resistance by activating cryptic multidrug efflux pumps in AcrB-Null

Hao-Jie Shen, Jun-Feng Wang, Zheng-Jie Xue, Jia-Qi Shi, Bing Chen, Dong-Min Chen, Ni-Pi Chen, Yu-Dong Li, Chao-Dong Qian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virulence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Cryptotanshinone inhibitsVirulence · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hao-Jie ShenCollege of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Jun-Feng WangCollege of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Zheng-Jie XueCollege of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Jia-Qi ShiCollege of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Bing ChenCollege of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Dong-Min ChenCollege of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Ni-Pi ChenCollege of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Yu-Dong LiSchool of Food sciences and Biotechnology, Zhejiang Gongshang University, Hangzhou, China.
Chao-Dong QianCollege of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China.ORCID 0000-0002-1646-7639

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance is one of the greatest threats to global health. A thorough comprehension of the underlying processes through which bacteria evolve the ability to withstand diverse stressors is vital for the development of efficacious strategies to address this challenge. This study aimed to elucidate the mechanisms underlying the adaptation of an

Indexed as

Anti-Bacterial AgentsATP-Binding Cassette, Sub-Family C ProteinsBenzophenanthridinesDrug Resistance, Multiple, BacterialEscherichia coliEscherichia coli ProteinsIsoquinolinesMembrane Transport ProteinsMutationGene Expression Regulation, BacterialMicrobial Sensitivity TestsOperonAcrB protein, E coliAnti-Bacterial AgentsATP-Binding Cassette, Sub-Family C ProteinsBenzophenanthridinesEscherichia coli ProteinsIsoquinolinesMembrane Transport Proteinssanguinarineefflux pumpEscherichia colimultidrug resistanceresistance-nodulation-cell division (RND) pumpsanguinarineTetR family regulator

Identifiers

PMID41017561
PMCPMC12482432

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.