Evidence map›Paper›PMID 41017463›Full record

ArticleCirculation. Cardiovascular imaging2025

Intramyocardial Hydrogel Delivery Decreases Left Ventricular Remodeling and Increases Angiogenesis Post Myocardial Infarction.

Inga H Melvinsdottir, Dan Midgett, Shin Rong Lee, Stephanie L Thorn, Selen Uman, Ricardo Avendaño, Taras Lysyy, Fatema Tuj Zohora, Kevin Chen, Marina Mamarian and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Cardiovascular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Inga H MelvinsdottirSection of Cardiovascular Medicine, Department of Internal Medicine (I.H.M., S.L.T., R.A., F.T.Z., A.J.S.), Yale University, New Haven, CT.
Dan MidgettJohns Hopkins Applied Physics Laboratory, Johns Hopkins University, Laurel, MD (D.M.).ORCID 0000-0003-1173-0917
Shin Rong LeeDepartment of General Surgery (S.R.L.), Yale University, New Haven, CT.ORCID 0000-0003-1979-1204
Stephanie L ThornSection of Cardiovascular Medicine, Department of Internal Medicine (I.H.M., S.L.T., R.A., F.T.Z., A.J.S.), Yale University, New Haven, CT.ORCID 0000-0003-0020-0814
Selen UmanDepartment of Bioengineering, University of Pennsylvania, Philadelphia (S.U., J.A.B.).
Ricardo AvendañoSection of Cardiovascular Medicine, Department of Internal Medicine (I.H.M., S.L.T., R.A., F.T.Z., A.J.S.), Yale University, New Haven, CT.ORCID 0000-0002-3454-2903
Taras LysyySection of Transplantation and Immunology, Department of Surgery (T.L.), Yale University, New Haven, CT.ORCID 0000-0002-6210-7407
Fatema Tuj ZohoraSection of Cardiovascular Medicine, Department of Internal Medicine (I.H.M., S.L.T., R.A., F.T.Z., A.J.S.), Yale University, New Haven, CT.ORCID 0000-0002-9037-7826
Kevin ChenSection of Cardiovascular Medicine, Department of Internal Medicine (I.H.M., S.L.T., R.A., F.T.Z., A.J.S.), Yale University, New Haven, CT.ORCID 0000-0003-3330-8717
Marina MamarianDepartment of Internal Medicine, Yale Translational Research Imaging Center (I.H.M., S.L.T., R.A., F.T.Z., K.C., M.M., A.J.S.), Yale University, New Haven, CT.
James S DuncanDepartment of Radiology and Biomedical Imaging (J.S.D., A.J.S.), Yale University, New Haven, CT.ORCID 0000-0002-5167-9856
Francis G SpinaleDepartment of Cell Biology and Anatomy and Cardiovascular Research Center, University of South Carolina School of Medicine and the Columbia VA Health Care System (F.G.S.).ORCID 0000-0003-0529-5605
Jason A BurdickDepartment of Bioengineering, University of Pennsylvania, Philadelphia (S.U., J.A.B.).ORCID 0000-0002-2006-332X
Albert J SinusasSection of Cardiovascular Medicine, Department of Internal Medicine (I.H.M., S.L.T., R.A., F.T.Z., A.J.S.), Yale University, New Haven, CT.ORCID 0000-0003-0972-9589

Funding

Training In Multi-modality Molecular & Translational Cardiovascular ImagingT32HL098069 · NHLBI · YALE UNIVERSITY · PI JAMES S DUNCAN, Georges El Fakhri · 2010 to 2026
$5.2M
Image Guided Delivery of Bioresponsive HydrogelsR01HL137365 · NHLBI · YALE UNIVERSITY · PI BURDICK, JASON A, DUNCAN, JAMES S · 2018 to 2021
$3.2M
Fibroblast targeting for myocardial repairR01HL167994 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FRANCIS G SPINALE · 2023 to 2026
$2.6M
Hybrid Volumetric SPECT/CT Imaging SystemS10RR025555 · NCRR · YALE UNIVERSITY · PI SINUSAS, ALBERT J · 2009 to 2009
$500k
BLRD VA I01 BX000168BLRD VA I01 BX005320NCRR NIH HHS S10 RR025555NHLBI NIH HHS R01 HL137365NHLBI NIH HHS R01 HL167994NHLBI NIH HHS T32 HL098069
6 · The paper itself

Abstract

backgroundIntramyocardial injection of hydrogel into myocardial infarction (MI) areas can reduce left ventricular remodeling and potentially increase angiogenesis post-MI. The radiotracer

methodsFourteen pigs (N=14) underwent 90 minutes of balloon occlusion and reperfusion. Five days post-MI, they were randomized to receive either intramyocardial hydrogel (n=8) or control saline injections (n=6). Contrast cine-computed tomography was used to assess biomechanical changes before and after treatment (day 1, day 5, and day 12).

resultsBoth groups initially showed a decrease in ejection fraction and an increase in end-diastolic volume post-MI. Hydrogel delivery on day 5 led to a reduction in end-diastolic volume and improvement in left ventricular ejection fraction by day 12. The hydrogel group also exhibited decreased compensatory radial strain in remote myocardial segments, but decreased strain in the hydrogel myocardial segments. There was increased uptake of

conclusionsIntramyocardial delivery of hydrogel early post-MI resulted in decreased left ventricular remodeling and increased αvβ3-integrin activation associated with an increase in angiogenesis.

Indexed as

AngiogenesisHydrogelsMyocardial InfarctionVentricular RemodelingAnimalsCardiac Imaging TechniquesFemaleInjections, IntralesionalIntegrin alphaVbeta3MaleMyocardiumOrganotechnetium CompoundsPrecision MedicineRandom AllocationSingle Photon Emission Computed Tomography Computed TomographyStroke VolumeHydrogelsIntegrin alphaVbeta3Organotechnetium Compoundsangiogenesishydrogelsmultimodal imagingmyocardial infarctiontomography, spiral computed

Identifiers

PMID41017463
PMCPMC13041719

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.