Evidence map›Paper›PMID 41017413›Full record

Trial reportPhysiological reports2025

Histamine-receptor blockade does not influence the heavy-severe domain boundary and time to task failure in the severe domain during cycling exercise in adults.

Kieran S S Abbotts, Jake H Hudgins, Isabella S Viveros, Christopher T Minson, Brad W Wilkins, John R Halliwill

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kieran S S AbbottsDepartment of Human Physiology, University of Oregon, Eugene, Oregon, USA.
Jake H HudginsDepartment of Human Physiology, University of Oregon, Eugene, Oregon, USA.
Isabella S ViverosDepartment of Human Physiology, University of Oregon, Eugene, Oregon, USA.
Christopher T MinsonDepartment of Human Physiology, University of Oregon, Eugene, Oregon, USA.
Brad W WilkinsDepartment of Human Physiology, University of Oregon, Eugene, Oregon, USA.
John R HalliwillDepartment of Human Physiology, University of Oregon, Eugene, Oregon, USA.ORCID 0000-0003-3001-1715

Funding

Histamine as a Molecular Transducer of Adaptation to ExerciseR01AG072805 · NIA · UNIVERSITY OF OREGON · PI HALLIWILL, JOHN R., MINSON, CHRISTOPHER TODD · 2021 to 2025
$2.4M
Eugene and Clarissa Evonuk Memorial Graduate FellowshipNIA NIH HHS R01 AG072805University of Oregon Department of Human PhysiologyWu Tsai Human Performance Alliance and the Joe and Clara Tsai Foundation
6 · The paper itself

Abstract

The influence of histamine in skeletal muscle during exercise is poorly characterized. This investigation tested the hypothesis that histamine-receptor blockade lowers the power associated with the heavy-severe domain boundary and reduces time to task failure in the severe domain. Following a graded exercise test and a familiarization trial, 17 participants (8 M/9 F, 29 ± 8 years, VO

Indexed as

BicyclingExerciseHistamine AntagonistsMuscle, SkeletalAdultCross-Over StudiesDouble-Blind MethodExercise TestFemaleHumansMaleOxygen ConsumptionYoung AdultHistamine Antagonistsallergiesbicyclingexercise performanceexercise thresholdsfatiguehistaminephysiology

Identifiers

PMID41017413
PMCPMC12477431

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.