Evidence map›Paper›PMID 41017402›Full record

ArticleZoological research2025

Coordinated inhibition of M1 macrophage polarization by FIT2-mediated lipid droplet biosynthesis and FABP5.

Yi-Han Liu, Bei Li, Yuan-Xing Zhang, Sang Ho Choi, Shuai Shao, Qi-Yao Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zoological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yi-Han LiuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
Bei LiState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
Yuan-Xing ZhangLaboratory of Aquatic Animal Diseases of MARA, Shanghai 200237, China.
Sang Ho ChoiNational Research Laboratory of Molecular Microbiology and Toxicology, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-742, Republic of Korea.
Shuai ShaoState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
Qi-Yao WangState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipid droplets (LDs) serve as dynamic organelles central to host immune response and bacterial infection resistance by recruiting multiple proteins and peptides with established antiviral and antibacterial properties. Although macrophage polarization is integral to both innate immunity and lipid homeostasis, the regulatory influence of LDs on this process remains unclear. In this study, augmentation of LDs via oleic acid (OA) treatment attenuated M1 polarization in RAW264.7 macrophages. Given that LD budding is mediated by fat storage-inducing transmembrane protein 2 (FIT2) encoded by

Indexed as

Fatty Acid-Binding ProteinsLipid DropletsMacrophagesMembrane ProteinsAnimalsGene Expression RegulationLipid MetabolismMiceNeoplasm ProteinsOleic AcidRAW 264.7 CellsFabp5 protein, mouseFatty Acid-Binding ProteinsMembrane ProteinsNeoplasm ProteinsOleic AcidFABP5FIT2Lipid dropletMacrophage polarization

Identifiers

PMID41017402
PMCPMC12780504

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.