Evidence map›Paper›PMID 41017376›Full record

ArticlePhysiological reports2025

Association between muscle sympathetic nerve activity and red blood cell distribution width in adults.

Gavin W Lambert, Carolina Ika Sari, Nora E Straznicky, John B Dixon, Nina Eikelis, Murray D Esler, Markus P Schlaich, Elisabeth A Lambert

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In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gavin W LambertIverson Health Innovation Research Institute, Swinburne University of Technology, Hawthorn, Australia.ORCID 0000-0003-0315-645X
Carolina Ika SariBaker Heart & Diabetes Institute, Melbourne, Australia.
Nora E StraznickyBaker Heart & Diabetes Institute, Melbourne, Australia.
John B DixonIverson Health Innovation Research Institute, Swinburne University of Technology, Hawthorn, Australia.ORCID 0000-0001-6399-7010
Nina EikelisIverson Health Innovation Research Institute, Swinburne University of Technology, Hawthorn, Australia.
Murray D EslerBaker Heart & Diabetes Institute, Melbourne, Australia.
Markus P SchlaichDobney Hypertension Centre, School of Medicine and Pharmacology, Royal Perth Hospital Unit, University of Western Australia, Perth, Australia.
Elisabeth A LambertIverson Health Innovation Research Institute, Swinburne University of Technology, Hawthorn, Australia.

Funding

Swinburne University of Technology
6 · The paper itself

Abstract

Measures obtained from the full blood count have been shown to vary around a set point, are stable over years, and provide an indication of disease risk and mortality. In this study, we examined the association between sympathetic nerve activity and components of the full blood count. We performed a retrospective analysis of data drawn from our clinical database. Subjects were included if available data comprised full blood count and muscle sympathetic nerve activity (MSNA). Data were obtained from 160 individuals, comprising healthy volunteers, subjects who were overweight or with clinical obesity, and patients with high blood pressure. MSNA was correlated to the red cell distribution width (RDW, Spearman's rho 0.49 for MSNA b/min and 0.48 for MSNA b/100hb, p < 0.001 for both), but bore no association with any of the other blood variables. Regression analysis indicated that the RDW could be predicted by a combination of MSNA and BMI and to the number of components and diagnosis of the metabolic syndrome, measures of insulin resistance, and markers of inflammation. Our observations may provide insight into the possible mechanisms linking the RDW with mortality.

Indexed as

Erythrocyte IndicesErythrocytesMuscle, SkeletalSympathetic Nervous SystemAdultAgedBody Mass IndexFemaleHumansHypertensionMaleMiddle AgedObesityRetrospective Studiesfull blood counthematologymetabolic syndromeobesity

Identifiers

PMID41017376
PMCPMC12477434

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.