ArticleObesity (Silver Spring, Md.)2025
Body Roundness Index Associated With Cardiometabolic Multimorbidity and Mortality: A Multistate Model.
Article in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The trial behind it
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Who cites it
5 citing papers in PubMed.
- Early Pregnancy Body Roundness Index and Development of Adverse Pregnancy Outcomes: A Secondary Analysis of the nuMoM2b Study.Obesity (Silver Spring, Md.) · 2026Observational
- Joint assessment of white blood cell-to-HDL cholesterol ratio and waist-to-height-hemoglobin A1c for cardiometabolic multimorbidity risk: a prospective cohort study and cross-sectional study.Frontiers in nutrition · 2026Article
- Comparative discriminatory performance of emerging endocrine-metabolic indices versus obesity indices for cardiometabolic multimorbidity in older adults: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Body Roundness Index Associated With Cardiometabolic Multimorbidity and Mortality: A Multistate Model.Obesity (Silver Spring, Md.) · 2025Article
- BRI shows stronger association than BMI for MACE in patients with T2DM: insights from the ACCORD study.Frontiers in nutrition · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to investigate the associations of body roundness index (BRI) with cardiometabolic disease (CMD), cardiometabolic multimorbidity (CMM), and all-cause mortality, while evaluating its impact across different stages of CMM progression.
methodsIn this prospective cohort study, 87,902 participants from the Kailuan cohort were categorized into BRI quartiles. Cox models estimated hazard ratios (HRs) and 95% CIs for the first occurrence of cardiometabolic disease (FCMD), CMM, and mortality. Multistate models assessed BRI's role across CMM progression.
resultsOver a median follow-up of 13.68 years, 21,636 participants developed FCMD, 2114 developed CMM, and 14,782 died. Elevated BRI increased risks of FCMD, CMM, and mortality in Cox models. Multistate analysis revealed differential BRI effects across CMM progression: participants in the highest versus lowest BRI quartile showed HRs of 2.08 (1.99-2.17) for healthy-to-FCMD transition, 1.61 (1.38-1.88) for FCMD-to-CMM transition, and 1.09 (1.03-1.16), 0.99 (0.89-1.10), and 0.73 (0.54-0.99) for mortality from the healthy state, FCMD, and CMM, respectively. BRI's impact varied by disease type (diabetes mellitus, myocardial infarction, stroke) and sex, with stronger associations in females.
conclusionsOur findings emphasize dynamic BRI monitoring as a biomarker for early CMM risk identification and prognostic assessment, necessitating disease- and sex-specific prevention strategies.
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