ArticleJournal of human nutrition and dietetics : the official journal of the British Dietetic Association2025
Clinical Outcomes and Food Triggers Following Low Food Chemical Diet Implementation: A Retrospective Audit of Dietetic Practice.
Article in Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Diet Stacking - An Expanding Challenge for Gastroenterologists and Dietitians in Managing Chronic Gastrointestinal Disorders.JGH open : an open access journal of gastroenterology and hepatology · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
introductionFood hypersensitivity describes a range of nonimmune food related reactions of varying aetiology causing gastrointestinal and extraintestinal symptoms. This study aimed to evaluate if the low-chemical diet improves gastrointestinal and/or extraintestinal symptoms, and whether specific food challenges induce symptoms.
methodsA retrospective clinical audit was conducted on files from 2011 to 2022 from a gastrointestinal specialist dietetic practice. Fifty eligible patient files were identified, all of whom had been recommended to follow a low-chemical diet. One research dietitian extracted data on diet implementation, symptom change during the Restrictive Phase, and symptom provocation during the Rechallenge Phase. Descriptive statistics were used.
resultsThe cohort was predominantly female (80%), mean age 47 years (range 7-85). At baseline the most common gastrointestinal symptom was diarrhoea (22/50, 44%), and extraintestinal symptom was nasal congestion (14/50, 28%). Improvement in at least one symptom following the Restrictive Phase occurred in 88% (44/50). The Restrictive Phase was followed for 2-78 weeks, and unintentional weight loss was documented in 24% (2-10 kg). The Rechallenge Phase duration ranged from 5 to 191 weeks, with 96% (48/50) reporting symptom provocation following at least one challenge. Salicylate challenge most commonly induced diarrhoea (16%), bloating (16%), and itch (14%), while amine challenge induced abdominal pain (10%) and nausea (8%).
conclusionPatients reported an improvement in gastrointestinal and extraintestinal symptoms, but commonly experienced prolonged dietary restriction. Rechallenge with salicylates and amines provoked symptoms; but this may be confounded by other diet and non-diet factors. High-quality trials with isolated food chemical components are needed.
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