Evidence map›Paper›PMID 41017090›Full record

ReviewCurrent topics in medicinal chemistry2026

Viral Vertical Transmission through the Placenta: The Potential of Natural Products as Therapeutic and Prophylactic Antiviral Agents.

Ana Flavia S Lima, Rayane M Botelho, Marilene B T Fragoso, Miguel L Silva, Jadriane A Xavier, Alexandre U Borbely, Marilia O F Goulart

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current topics in medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Placental Barrier Breakdown Induced byInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ana Flavia S LimaInstitute of Biological and Health Sciences, Federal University of Alagoas, Maceio, Alagoas, Brazil.ORCID 0000-0003-3537-8380
Rayane M BotelhoInstitute of Biological and Health Sciences, Federal University of Alagoas, Maceio, Alagoas, Brazil.ORCID 0000-0002-5941-3550
Marilene B T FragosoInstitute of Chemistry and Biotechnology, Federal University of Alagoas, Maceio, Alagoas, Brazil.ORCID 0000-0002-7504-0491
Miguel L SilvaInstitute of Chemistry and Biotechnology, Federal University of Alagoas, Maceio, Alagoas, Brazil.ORCID 0000-0003-2655-3917
Jadriane A XavierInstitute of Chemistry and Biotechnology, Federal University of Alagoas, Maceio, Alagoas, Brazil.ORCID 0000-0002-2878-5589
Alexandre U BorbelyInstitute of Biological and Health Sciences, Federal University of Alagoas, Maceio, Alagoas, Brazil.ORCID 0000-0001-6737-0901
Marilia O F GoulartInstitute of Chemistry and Biotechnology, Federal University of Alagoas, Maceio, Alagoas, Brazil.ORCID 0000-0001-9860-3667

Funding

CAPES/PROEX (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) 88881.894490/2023-01FAPEAL (Fundação de Amparo à Pesquisa do Estado de Alagoas/CNPq) 60030.0000000322/2023INCT-Bioanalítica (Instituto Nacional de Ciências e Tecnologia em Bioanalítica) 465389/2014-7
6 · The paper itself

Abstract

Pregnant women are among the most vulnerable groups in human populations. The human placenta, consisting of fetal chorionic villi and maternal basal decidua, is a specialized and transient organ crucial for supporting pregnancy and ensuring the well-being of both the mother and the fetus. Although the placenta has a developed, robust defense system, some pathogens can overcome it and cause a fetal infection that may be lethal. This review examines the defense mechanisms in the placenta against viral infections, how microorganisms bypass these defense barriers to cause illness, and the potential use of natural products in treating viral infections during pregnancy. Research on natural products has shown their promise to serve as an alternative to antiviral therapy, particularly for pregnant women.

Indexed as

Antiviral AgentsBiological ProductsInfectious Disease Transmission, VerticalPlacentaPregnancy Complications, InfectiousVirus DiseasesFemaleHumansPregnancyAntiviral AgentsBiological ProductsAntiviralnatural productsplacentapregnancyprophylaxistherapeutic agents.

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.