Evidence map›Paper›PMID 41017049›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Multispectral Chiral Quasi-Bound States in the Continuum Enabled Microfluidics for High-Throughput Molecular Screening and Quantification.

Xinyue Liang, Zihan Zhao, Xiaocong Tang, Haiyue Yang, Lanju Liang, Meng Zhao, Cong Wang, Lei Wang, Xumin Ding

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xinyue LiangAdvanced Microscopy and Instrumentation Research Center, School of Instrumentation Science and Engineering, Harbin Institute of Technology, Harbin, 150080, China.
Zihan ZhaoAdvanced Microscopy and Instrumentation Research Center, School of Instrumentation Science and Engineering, Harbin Institute of Technology, Harbin, 150080, China.
Xiaocong TangDepartment of Microwave Engineering, Harbin Institute of Technology, Harbin, 150001, China.
Haiyue YangState Key Laboratory of Advanced Inorganic Fibers and Composites, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China.
Lanju LiangSchool of Opto-electronic Engineering, Zaozhuang University, Zaozhuang, 277160, China.
Meng ZhaoJiangsu Key Laboratory of Micro and Nano Heat Fluid Flow Technology and Energy Application, School of Mathematics and Physics, Suzhou University of Science and Technology, Suzhou, 215009, China.
Cong WangDepartment of Microwave Engineering, Harbin Institute of Technology, Harbin, 150001, China.
Lei WangState Key Laboratory of Advanced Inorganic Fibers and Composites, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China.
Xumin DingAdvanced Microscopy and Instrumentation Research Center, School of Instrumentation Science and Engineering, Harbin Institute of Technology, Harbin, 150080, China.ORCID https://orcid.org/0000-0002-7725-790X

Funding

Fundamental Research Funds for the Central Universities XNJKKGYDJ2024007National Natural Science Foundation of China 62275063National Natural Science Foundation of China 623B2030Young Elite Scientists Sponsorship Program
6 · The paper itself

Abstract

Traditional chiral detection methods often suffer from label dependence and limited throughput, hindering accurate profiling of trace enantiomers. Herein, a terahertz (THz) multispectral metachip-enabled microfluidic platform is presented for label-free, high-throughput screening and quantitation of chiral molecules. The metachip integrates arrayed pixels engineered with chiral quasi-bound states in the continuum (q-BIC), generating high circular dichroism (CD) across 0.5-2.0 THz. On-chip microfluidic integration enables multi-dimensional CD feature extraction in aqueous environments, while the Uniform Manifold Approximation and Projection (UMAP) algorithm maps multidimensional CD features into a Two-dimensional (2D) spectrum, simultaneously realizing conformation identification and concentration quantification (0.05-0.3 mg dL

Indexed as

High-Throughput Screening AssaysMicrofluidic Analytical TechniquesMicrofluidicsCircular DichroismLab-On-A-Chip DevicesStereoisomerismchiral quasi‐bound states in the continuummetachipmicrofluidicsmolecular detection

Identifiers

PMID41017049
PMCPMC12713036

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.