Evidence map›Paper›PMID 41016965›Full record

SynthesisFrontiers of medicine2025

Global, regional and national burden and trends of congenital musculoskeletal and limb deformities among under-5 children from 1990 to 2021: a systematic analysis for the Global Burden of Disease Study 2021.

Qinglin Yang, Zhuanmei Jin, Yongping Wang

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Frontiers of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Qinglin YangThe First Clinical Medical College of Lanzhou University, Lanzhou, 730000, China.
Zhuanmei JinThe First Clinical Medical College of Lanzhou University, Lanzhou, 730000, China.
Yongping WangDepartment of Orthopedics, the Second Affiliated Hospital of Hainan Medical University, Haikou, 570311, China. wangyp0312@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital musculoskeletal and limb deformities (CMLD) seriously affect the physical and mental health of patients, and pose great challenges to healthcare systems worldwide. We explored the specific situation and changes of incidence, prevalence, disability-adjusted life years rates, and mortality of CMLD in under-5 children from 1990 to 2021 in different groups, including different regions, periods, genders and socio-demographic indices (SDI), through corresponding analytical models. Overall, the global disease burden of CMLD in under-5 children has decreased from 1990 to 2021. The disease burden of CMLD in under-5 children varied significantly among different regions and countries, and there was a strong correlation between the corresponding burden of disease and the level of SDI. In addition, cross-country inequality analysis showed that while absolute inequalities in the disease burden of CMLD in under-5 children have improved, relative inequalities have worsened. It is essential to reduce the global health impact of CMLD by implementing targeted interventions to improve health care in underdeveloped areas.

Indexed as

Global Burden of DiseaseLimb Deformities, CongenitalMusculoskeletal AbnormalitiesChild, PreschoolCost of IllnessDisability-Adjusted Life YearsFemaleGlobal HealthHumansIncidenceInfantInfant, NewbornMalePrevalenceSocioeconomic Factorscongenital musculoskeletal and limb deformitiesdisability-adjusted life yearsglobal burden of diseaseincidenceprevalencetrend

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.