ArticleEcho research and practice2025
Left ventricular myocardial strain in neonates is influenced by the definition of the basal region of interest.
Article in Echo research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePrevious studies have examined the effects of various acquisition- and post-processing parameters such as frame rate/heart rate ratio, probe frequency, smoothing, drift compensation, and region of interest width on strain in the perinatal age group. The aim of this study was to examine how measurement of left ventricular strain is influenced by different definitions of the basal region of interest.
methodsTransthoracic echocardiography was performed on 41 healthy neonates within ten days after birth. Left ventricle longitudinal strain was assessed in four-, three-, and two-chamber views, with global longitudinal strain calculated as a mean of these. Segmental and layer-specific strains were measured in the four-chamber view. During image processing, the basal region of interest was placed at four different levels in early diastole, ranging from the mitral valve annulus (level 1) to the leaflet tips (level 4).
resultsDisplacement of the basal region of interest from level 1 to level 4 resulted in a significant change in longitudinal strain values between : from − 19.0% to -20.6% for global longitudinal strain, and from − 18.5% to -20.7%, -19.4% to -20.1%, and − 19.2% to -21.0% for four-chamber, three-chamber and two-chamber strain, respectively (p < 0.001 for all measures). Similar changes were observed for segmental and layer-specific longitudinal strain analyses.
conclusionThe placement of the basal region of interest significantly impacted left ventricular strain measurements in neonates. These findings highlight the importance of precise and consistent region of interest positioning to ensure reproducible myocardial function assessments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.