ArticleJournal of gastroenterology and hepatology2025
Comparative Analysis of Physical and Polymer Characteristics of Microplastics Detected in Human Colorectal Cancer Samples From the United States and Malaysia.
Article in Journal of gastroenterology and hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Marine microplastic pollution and cancer incidence from 2013 to 2021 in US coastal counties: an ecological analysis.International journal of hygiene and environmental health · 2026Article
- Microplastics and Nanoplastics in the Human Diet: Sources of Exposure, Bioavailability, Toxicokinetics, and Systemic Health Effects.Molecules (Basel, Switzerland) · 2026Review
- The link between microplastics and colorectal cancer.Cancer metastasis reviews · 2026Review
- Emerging evidence on micro- and nanoplastics carcinogenicity: mechanisms, models, and signaling networks.Molecular cancer · 2026Review
- Microplastics' Impact on the Development of AOM/DSS-Induced Colitis-Associated Colorectal Cancer in Mice.International journal of molecular sciences · 2025Article
- Comparative Analysis of Physical and Polymer Characteristics of Microplastics Detected in Human Colorectal Cancer Samples From the United States and Malaysia.Journal of gastroenterology and hepatology · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
BACKGROUND AND
aimsPrevious studies have detected microplastics in bowel tissues, but have been limited by small sample sizes. Our study expanded the data collection from two countries at different time points (United States from 1993 to 1999 and Malaysia from 2023 to 2024) with the aim of comparing the physical and polymer characteristics of microplastics found in colorectal cancer samples. MATERIALS AND
methodsMicroplastics were extracted from the tissues using a chemical digestion method of 10% potassium hydroxide, and examined under a stereomicroscope. Further surface morphology and polymeric composition were analyzed with a scanning electron microscope and micro-Fourier transform infrared spectroscopy.
resultsMicroplastics were detected in all 50 samples (25 from the United States and 25 from Malaysia), with a higher abundance found in the Malaysian samples (32.2 ± 48.14 particles/g) compared to the American samples (25.00 ± 40.57 particles/g). Both population samples exhibited similar shapes, with fibers being the most abundant. American samples have longer microplastics (Category II = 501-1000 µm) than the Malaysian samples (Category I = < 500 µm). Both population samples exhibited surface roughness on their microplastics and similar polymer types including polyethylene (PE), polypropylene (PP), polyamide (PA) and polycarbonate (PC). Acrylonitrile butadiene styrene (ABS) was only observed in the American samples.
conclusionMicroplastics are detected in colorectal cancer samples of both populations collected from two different time points but with similar and also distinct physical and polymer characteristics.
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Registered trials
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